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The THALES Trial: Ticagrelor and Aspirin vs Aspirin Alone in Acute Ischemic Stroke or TIA

Background: The risk of a subsequent ischemic stroke in the first few months after an acute ischemic stroke or transient ischemic attack is approximately 5 to 10%. In these patients Aspirin has been used to prevent secondary ischemia, and trials ...

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Neurology

REBEL Core Cast 39.0 – Upper GI Bleed

Take Home Points Focus on resuscitating well by focusing on the basics Recognize Massive GIB (MGIB) with a thorough exam of the patient and vital signs (Shock index >0.7 is ABNORMAL and signals impending shock) Obtain large bore PIV access ...

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Abdominal and Gastrointestinal

Multisystem Inflammatory Syndrome in Children (MIS-C) vs Kawasaki Disease

Case Presentation: A 4-year-old previously healthy Hispanic female presented to the ED with a diffuse rash and facial swelling, concerning for an apparent allergic reaction. She was rushed into the treatment area for evaluation of possible anaphylaxis and respiratory assessment. ...

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Infectious DiseasePediatrics

Infectious Acute Transverse Myelitis Secondary to COVID-19

The Coronaviridae family and its genera coronaviruses have been implicated as having neurotropic and neuroinvasive capabilities in human hosts (Bohmwald 2018). They have been associated with the development of neuropsychiatric symptoms, seizure activity, encephalomyelitis, acute flaccid paralysis, cerebral venous sinus ...

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Infectious DiseaseNeurology

STARRT-AKI Trial: Timing of Renal Replacement Therapy Initiation in Acute Kidney Injury

Background Information: It is well documented throughout the literature that critically ill patients admitted to the intensive care unit (ICU) with acute kidney injury have a higher morbidity and mortality.1–4 Acute kidney injury may be complicated by acidosis, hyperkalemia and ...

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Endocrine, Metabolic, Fluid, and ElectrolytesRenal and Genitourinary

GRECCO-19: Colchicine for COVID-19?

Background: The most severe SARS-CoV-2 infections result in an intense inflammatory response which can lead to acute lung injury and/or acute respiratory distress syndrome.  Theoretically, potential treatments for severe disease should have anti-inflammatory action without substantial side effects. One candidate ...

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Infectious Disease

The VEINART Trial: VBG vs ABG

Background: Patients coming to the ED frequently have several interventions performed in their evaluation and management.  Blood draws, for the most part, are venous. Occasionally, however, arterial sampling is used to gauge acid-base status, PaO2, PaCO2, lactate etc.  This is ...

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Procedures and Skills

Can We Predict Which COVID-19 Patients Will Decompensate?

Background: As the COVID-19 pandemic continues a number of challenges have arisen. Amongst these is the ability of clinicians to predict which patients will suffer from early decompensation. It is well established that there are patients that will rapidly decline ...

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Infectious Disease

REBEL Core Cast 38.0 – Productivity

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Therapy Options in Acute Respiratory Distress Syndrome

 Background Information: The care and management of patients with acute respiratory distress syndrome (ARDS) is complex and follows an inciting injury to the lungs. This constellation of symptoms is characterized by hypoxemia, diffuse lung inflammation, decreased lung compliance and noncardiogenic ...

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Thoracic and Respiratory
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