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Medical Category: Infectious Disease

The ACORN Trial: Battle of the Gorilla-Cillins (Cefepime vs Piperacillin-Tazobactam)

Background: Acutely ill adults presenting to the hospital with suspected infection commonly receive empiric, broad-spectrum antibiotics as part of their initial management including coverage of both MRSA and pseudomonas species.  MRSA coverage includes the use of vancomycin while anti-pseudomonal coverage …

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Infectious Disease

Clinical Conundrums: Should I Provide Patients with Pharyngitis a Dose of Corticosteroids

Bottom Line Up Top: Steroids provide modest improvement in time to resolution and degree of resolution of symptoms in pharyngitis. They should be considered in patients presenting to the ED after weighing potential benefits and risks. Clinical Scenario: A 22-year-old …

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Head, Eye, Ear, Nose, and ThroatInfectious Disease

How Much O2 Is Right in COVID?

Background: Hypoxemic respiratory failure is a frequent complicating feature of severe COVID-19 infection. Early in the pandemic, extensive efforts were made to identify the best approach to oxygenation in this group of patients. Best practices settled on aggressive use of …

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Infectious Disease

Pre-Hospital Antibiotics in Sepsis?

Background: Sepsis remains one of the leading causes of morbidity and mortality. It is well-established that earlier recognition and treatment can lead to better outcome for these patients .  Time to antibiotic therapy (from triage, not from onset of infection) has …

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Infectious Disease

Clinical Conundrums: Should You Give the First Dose of Antibiotics IV Before Discharging Home on Oral Antibiotics?

Bottom Line Up Top: In patients with infectious processes that are stable for discharge home, there is no role for giving a first dose of antibiotics IV in the ED. Clinical Scenario: A 45-year-old woman with hypertension presents with a …

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Infectious Disease

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