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Medical Category: Infectious Disease

Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with COVID-19

Background: The clinical burden of severe COVID-19 triggered a pharmaceutical race to find effective, easily accessible, oral treatments that could decrease the morbidity and mortality associated with the disease. Nirmatrelvir is an oral antiviral agent that inhibits the SARS-CoV2 main …

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Infectious Disease

REBEL Core Cast 122.0 – Neutropenic Fever

Take Home Points: There are many causes of neutropenia, chemotherapy being by far the most dangerous. Febrile neutropenia is a condition conveying high mortality. Early administration of antibiotics is the only factor known to reduce this mortality. For a patient …

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Infectious Disease

REBEL Core Cast 121.0 – Acute Sinusitis

Take Home Points Acute rhinosinusitis is a clinical diagnosis The vast majority of acute rhinosinusitis cases are viral in nature and do not require antibiotics Consider the use of antibiotics in select groups with severe disease or worsening symptoms after …

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Head, Eye, Ear, Nose, and ThroatInfectious Disease

The ACORN Trial: Battle of the Gorilla-Cillins (Cefepime vs Piperacillin-Tazobactam)

Background: Acutely ill adults presenting to the hospital with suspected infection commonly receive empiric, broad-spectrum antibiotics as part of their initial management including coverage of both MRSA and pseudomonas species.  MRSA coverage includes the use of vancomycin while anti-pseudomonal coverage …

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Infectious Disease

Clinical Conundrums: Should I Provide Patients with Pharyngitis a Dose of Corticosteroids

Bottom Line Up Top: Steroids provide modest improvement in time to resolution and degree of resolution of symptoms in pharyngitis. They should be considered in patients presenting to the ED after weighing potential benefits and risks. Clinical Scenario: A 22-year-old …

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Head, Eye, Ear, Nose, and ThroatInfectious Disease

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