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Medical Category: Infectious Disease

The COV-BOOST Trial: Safety and Immunogenicity of Boosters

Background: COVID-19 became an international pandemic in March of 2020, claiming the lives of millions of people worldwide. To combat this deadly virus, an unprecedented global effort led to the development of many new vaccines against COVID-19 within a year. …

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Infectious DiseaseThoracic and Respiratory

REBEL Core Cast 77.0 – Pyogenic Flexor Tenosynovitis

Take Home Points Think about flexor tenosynovitis in a patient with atraumatic finger pain.  They may have any combination of these signs: Tenderness along the course of the flexor tendon Symmetrical swelling of the finger – often called the sausage …

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Infectious DiseaseOrthopedics

The SCOUT–CAP Trial: 5d Abx vs. 10d Abx in Pediatric CAP

Background: The standard approach to treating pediatric community-acquired pneumonia (CAP) is a 10-day course of antibiotics. However, two high-quality randomized control trials challenged this standard within the last 12 months. The SAFER Trial [reviewed here] and CAP-IT Trial [reviewed here] found treatment for CAP in …

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Infectious DiseasePediatricsThoracic and Respiratory

The ACTION Trial: DOACs in Hospitalized Patients with COVID-19

Background: Patients hospitalized with COVID-19 are at increased risk for both arterial and venous thromboembolic disease. Multiple recent trials have investigated the efficacy of therapeutic or standard prophylactic anticoagulation in preventing thrombotic complications among patients with COVID-19 in a variety …

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CardiovascularInfectious DiseaseThoracic and Respiratory

The MICHELLE Trial: Anticoagulation Post-Discharge in Patients Hospitalized Secondary to COVID-19

Background: Patients diagnosed with COVID-19 have an increased risk of thromboembolic events, including pulmonary embolism and deep vein thrombosis (DVT). In addition, COVID-19 patients with increased coagulation parameters such as D-dimer, fibrin degradation products, prothrombin time, and activated partial thromboplastin …

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CardiovascularHematology and OncologyInfectious DiseaseThoracic and Respiratory

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