Background: Current trauma resuscitation prioritizes control of bleeding and uses massive transfusion protocols to prevent and treat coagulopathy. This is typically done in the form of massive transfusion protocols delivered in proportions that approach the composition of whole blood. Two strategies to help guide this replacement of blood products are conventional coagulation tests and viscoelastic hemostatic assays....Read More
Background: Blunt cerebrovascular injury (BCVI) is defined as carotid or vertebral artery injury due to blunt trauma. There are several screening criteria that have been developed to screen for this injury, however a significant number of patients may still be missed by these screening criteria. Although this is not a common injury, the potential complications if undiagnosed and untreated can be devastating. Current screening criteria (see below) have been refined and expanded over the years, but just how good are they?...Read More
Background: We have covered tranexamic acid (TXA) on this blog in several posts. Its use has been studied for everything that bleeds from abnormal uterine bleeding to GI hemorrhage and from multisystem trauma to intracranial hemorrhage. While over the past few years it has been touted as the wonderdrug for bleeding, newer research is beginning to challenge that thought (CRASH-3 trial, HALT-IT trial, etc.).
The CRASH-2 trial showed that early administration of TXA (within 3 hours) to trauma patients improved all-cause mortality. However, obtaining rapid IV access in low resource, rural, or combat settings can be challenging. Only recently has research been conducted about intramuscular administration of TXA. Actually…we should really say that there has been a resurgence of interest in IM TXA. There were a couple studies published about its pharmacokinetics and pharmacodynamics in the 1970s and 80s, followed by radio silence on the subject.1,2 Curiosity about the drug has picked back up over the past decade as its cost dropped and access to TXA increased exponentially. In fact, finding alternative routes of TXA administration in postpartum hemorrhage is a WHO priority.3
Today, we will review a recent article that explored the pharmacokinetics of intramuscular TXA in bleeding trauma patients....Read More
Orbital compartment syndrome (OCS) is a rare, vision-threatening diagnosis that requires rapid identification and immediate treatment for preservation of vision.1-4 As with other compartment syndromes, rapidly increasing and sustained high intraocular pressures (IOP) can result in devastating consequences. OCS causes retinal and optic nerve ischemia due to increased pressure on those structures. Due to the time-sensitive nature of this condition, the emergency physician (EP) plays a critical role in the diagnosis and management of OCS.5 The definitive therapy for this condition is lateral canthotomy and inferior cantholysis (LCIC).
Background: It almost seems that when it comes to the use of the antifibrinolytic agent tranexamic acid (TXA) in trauma, one argument has just been completed and another one comes up right behind it.
Let’s take a step back. Most agree that the evidence clearly supports the role of the early in-hospital administration of TXA in major trauma (in conjunction with balanced blood product transfusion practices). Given the benefit of in-hospital use, and the evidence supporting most benefit with earlier use, it seemed to make intuitive sense to bring this out into the prehospital setting closer to the point-of-injury – many agencies have done just that. However, this particular area of use did not have any associated high-quality evidence.
Led by a team out of the University of Pittsburgh (the same group that brought us the PAMPer trial in 2018), Guyette et al just released the Study of Tranexamic Acid During Air Medical and Ground Prehospital Transport (STAAMP) trial, published in JAMA Surgery....Read More