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REBEL Cast Ep95: Colchicine in COVID (COLCORONA)? Don’t Believe the Hype.

Background: Science by press release. Not the way any of us would choose to operate but, the COVID pandemic has made this a reality. It’s vital that we understand that while pharmaceutical companies have a responsibility to release this information, ...

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Infectious Disease

The RECOVERY Trial: Tocilizumab

Background: Publication of the RECOVERY trial results on Dexamethasone were game changing – the drug had a clear reduction in mortality in patients requiring oxygen. Since then, we have had little to celebrate in terms of therapeutics in those with ...

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Infectious Disease

APPAC II: Treatment of Uncomplicated Acute Appendicitis

Background: The recently published CODA trial (Link is HERE) comparing antibiotics vs laparoscopic appendectomy for acute uncomplicated appendicitis demonstrated  an antibiotic 1st strategy was non-inferior to laparoscopic appendectomy. However, there were nearly 3 in 10 patient who had undergone appendectomy ...

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Abdominal and Gastrointestinal

REBEL Core Cast 49.0 – Abdominal Aortic Aneurysm (AAA)

Take Home Points Consider ruptured AAA in patients (especially those > 50 years of age) with unexplained hypotension, back or abdominal pain All ruptured AAAs should be considered unstable regardless of vital signs as rapid deterioration is common A ruptured ...

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Cardiovascular

OMI-NOMI: Time for a Paradigm Shift

Background: What if we lived in a world where we didn’t call “STEMI alerts”, but instead paged out “OMI alerts”? In the Reperfusion Era of the late 20th century, many large trials showed the benefits of emergent reperfusion therapy, with even ...

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Cardiovascular

Wake Up In Beast Mode

What do Warren Buffet, Tim Cook, Michelle Obama, Oprah Winfrey, and Jack Dorsey have in common? They are all highly successful people with a penchant for rising early. Two additional people I find incredibly motivating, Jocko Willink and Eric Thomas, ...

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The RELAx Trial: What is the Optimal PEEP in Patients Without ARDS?

Background: It has well been established that low tidal volume ventilation minimizes potentially iatrogenic harms of mechanical ventilation.  What is less clear is the use of higher positive end expiratory pressure (PEEP) in patients without acute respiratory distress syndrome (ARDS). ...

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Thoracic and Respiratory

Corneal Abrasions and Short-Term Topical Tetracaine

Background: Anyone who has had a corneal abrasion knows how painful it can be.   Unfortunately, traditional analgesic agents (ibuprofen, acetaminophen, opiates etc) are ineffective in relieving pain. Topical anesthetic drops can be diagnostic of superficial eye pathology and are routinely ...

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Head, Eye, Ear, Nose, and Throat

REBEL Core Cast 48.0 Frostbite

Take Home Points Frostbite is a severe, localized cold-induced injury due to freezing and thawing of tissue. We usually see these injuries affecting the ears, nose, cheeks, chin, fingers, and toes. Patients will complain of cold, numb or stiff sensations ...

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Environmental

Resolute: Top 3 Productivity Tools for 2021

res·o·lute /ˈrezəˌl(y)o͞ot/ adjective: resolute admirably purposeful, determined, and unwavering. How do you find the time? How do you find the time to write that post? Or run the blog? Or prepare a lecture? How do you manage your professional and ...

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