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- Head, Eye, Ear, Nose, and Throat
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An Herbal Hope: Is XBJ A Game-Changer in Sepsis Management?
Background: Could Xuebijing (XBJ) catalyze a paradigm shift in sepsis management? XBJ is an herbal compound used in China to manage various inflammatory and infectious processes in recent years, including sepsis.2-6 It is an herbal preparation comprising a blend of ...
REBEL Cast Ep122 – Delayed vs Rapid Sequence Intubation in Agitated Trauma Patients
Background: Getting a definitive airway in a critically ill trauma patient can be a stressful situation. The potential for soiled airways, cervical spine injuries, maxillofacial injuries and head injuries combined with agitation/delirium, altered mental status and hypoxemia can make securing ...
AID-ICU Trial: Haloperidol for Treatment of ICU Delirium
Background Information: Delirium is a common and serious condition in patients in the intensive care unit (ICU). It is estimated to affect 30-50% of patients in the ICU and haloperidol is the most frequently used agent in treatment (3). One ...
The PALACE Trial: Direct Oral PCN Challenge in Patients with Low-Risk PCN Allergy?
Background: Many patients report a vague history of penicillin allergy. The vast majority of these self-reported allergies are untrue (< 5%) . Literature including patients with penicillin allergies also show longer, more complicated hospital courses. Standard practice for identifying errant allergy ...
REBEL Cast Ep121: The Battle of the Blades – Video Laryngoscopy vs. Direct Laryngoscopy
Background: The ongoing debate between video laryngoscopy (VL) and direct laryngoscopy (DL) has ignited intense debate within the emergency medicine and critical care communities. A recent pragmatic, randomized, multicenter trial (The DEVICE Trial) compared the two techniques to determine if ...
The ARAMIS Trial: DAPT vs Alteplase in Minor Nondisabling Acute Ischemic Stroke
Background: Current stroke guidelines recommend IV alteplase for patients with acute ischemic stroke presenting within 4.5hrs of symptom onset based on the NINDS and ECASS III publications. Both NINDS and ECASS III excluded patients with mild stroke symptoms but failed ...
REBEL Core Cast 105.0 – Methylxanthine Toxicity
Take Home Points Methylxanthines are a drug class that includes caffeine, theophylline, and theobromine. The three main mechanisms that account for the clinical presentation of methylxanthine toxicity are: catecholamine release, adenosine antagonism, and phosphodiesterase inhibition. Beta agonism will lead to ...
Peri-Intubation Hypotension – Dose Induction Dose Matter?
Background: Rapid Sequence Intubation (RSI) is a procedure fraught with potential complications including hypotension which, in turn, can result in cardiovascular collapse. While there are numerous potential causes of hypotension peri-RSI, induction medications represent an important, modifiable variable. Over the ...
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