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REBEL Core Cast 78.0 – Herpes Zoster

Take Home Points Classically, herpes zoster will present with rash and pain in a dermatomal distribution Immunocompromised patients are at greater risk for significant complications of zoster, including visceral dissemination and zoster ophthalmicus Appropriate therapy includes antiviral therapy within 72 ...

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DermatologyInfectious Disease

The INSPIRATION Trial: Intermediate Dose Anticoagulation in Critically Ill Patients with COVID-19

Background: COVID-19 infection increases the risk of thrombosis due to multiple factors.(Rico-Mesa, 2020). Over the last 2 years, researchers have published 12 RCTs investigating various anticoagulation strategies among patients diagnosed with COVID-19 in multiple clinical settings. To date, only a multiplatform ...

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CardiovascularHematology and OncologyInfectious DiseaseThoracic and Respiratory

The COV-BOOST Trial: Safety and Immunogenicity of Boosters

Background: COVID-19 became an international pandemic in March of 2020, claiming the lives of millions of people worldwide. To combat this deadly virus, an unprecedented global effort led to the development of many new vaccines against COVID-19 within a year. ...

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Infectious DiseaseThoracic and Respiratory

REBEL Core Cast 77.0 – Pyogenic Flexor Tenosynovitis

Take Home Points Think about flexor tenosynovitis in a patient with atraumatic finger pain.  They may have any combination of these signs: Tenderness along the course of the flexor tendon Symmetrical swelling of the finger – often called the sausage ...

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Infectious DiseaseOrthopedics

Effect of Intra-Arrest Transport and eCPR on Neurologic Outcomes in Refractory OHCA

Background Information: Refractory out of hospital cardiac arrest (OHCA) is defined as prolonged cardiac arrest and cardiac arrest without return of spontaneous circulation (ROSC). In addition to an already morbid condition, the chances of these patients surviving drops below 5% ...

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CardiovascularNeurologyResuscitation

The SCOUT–CAP Trial: 5d Abx vs. 10d Abx in Pediatric CAP

Background: The standard approach to treating pediatric community-acquired pneumonia (CAP) is a 10-day course of antibiotics. However, two high-quality randomized control trials challenged this standard within the last 12 months. The SAFER Trial  and CAP-IT Trial  found treatment for CAP in ...

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Infectious DiseasePediatricsThoracic and Respiratory

REBEL Cast Ep108: The PLUS Trial – Balanced vs Unbalanced Fluids in the Critically Ill

Background: In the past few years there has been a growing debate between  the use of balanced multielectrolyte solutions (BMES) and saline in the critically ill (See the “for more about this topic” section below). Recent research has yielded inconsistent ...

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Endocrine, Metabolic, Fluid, and Electrolytes

REBEL Core Cast 76.0 – Zoom Better

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Andexanet Alfa Vs. Four-Factor PCC: Is Andexanet Alfa Worth The Hype?

Background: Oral factor Xa inhibitors (FXi) have been associated with major and fatal bleeding events, including intracranial hemorrhage (ICH). In randomized controlled trials, both rivaroxaban and apixaban are associated with ICH at rates that range from 0.1 to 4% (Agnelli ...

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Hematology and OncologyNeurologyTrauma

The ACTION Trial: DOACs in Hospitalized Patients with COVID-19

Background: Patients hospitalized with COVID-19 are at increased risk for both arterial and venous thromboembolic disease. Multiple recent trials have investigated the efficacy of therapeutic or standard prophylactic anticoagulation in preventing thrombotic complications among patients with COVID-19 in a variety ...

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CardiovascularInfectious DiseaseThoracic and Respiratory
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