Archive

Author: Frank Lodeserto MD

The RELAx Trial: What is the Optimal PEEP in Patients Without ARDS?

Background: It has well been established that low tidal volume ventilation minimizes potentially iatrogenic harms of mechanical ventilation.  What is less clear is the use of higher positive end expiratory pressure (PEEP) in patients without acute respiratory distress syndrome (ARDS). …

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Thoracic and Respiratory

COVID-19 Update: The COVID-19 Pfizer Vaccine

Background: The COVID-19 Pfizer BNT162b2 vaccine, let’s just call it the COVID-19 Pfizer vaccine (so I don’t have to keep writing BNT162b2) is a novel mRNA vaccine developed to give immunity against the SARS CoV2 virus. It is synthesized mRNA packaged …

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Infectious Disease

Hemophagocytic Lymphohistiocytosis (HLH): A Zebra Diagnosis We Should All Know

What is it HLH? Hemophagocytic Lymphohistiocytosis (HLH) is a rare and often fatal syndrome of uncontrolled and ineffective inflammatory response to a certain trigger. It is characterized by excessive proliferation of lymphocytes and macrophages (histiocytes), hence the name “lymphohistiocytosis”. This …

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Hematology and Oncology

REBEL Crit Cast Ep 4.0: Lung Protective Mechanical Ventilation

Goals of lung protective mechanical ventilation: Minimizing harm during mechanical ventilation with a lung-protective strategy with: Low tidal volume (TV) Limit plateau pressure to <30mmHg Optimal positive end expiratory pressure (PEEP) set to decrease driving pressure

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Thoracic and Respiratory

REBEL Crit Cast Ep3.0: Airway Pressure Release Ventilation (APRV) Made Simple

Airway Pressure Release Ventilation (APRV) is a mode of ventilation that allows spontaneous breathing throughout the ventilation cycle.  It is a time-cycled mode of ventilation between two levels of positive airway pressure with the main time on the high level …

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Thoracic and Respiratory

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