Author: Salim Rezaie

The BOX Trial: BP & O2 Targets in Comatose Survivors of Cardiac Arrest

Background: Hypoxemia and hypoperfusion are important factors in outcomes after ROSC.  While hypoxemia (SpO2 <90%) is clearly deleterious, it is unclear if hyperoxia is beneficial.  Recent studies on patients requiring critical care have demonstrated that hyperoxia is harmful and instead …

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CardiovascularResuscitationThoracic and Respiratory

COCA Trial Follow-Up: Calcium vs Placebo on Long-Term Outcomes of OHCA

Background: The Calcium for Out-of-Hospital Cardiac Arrest (COCA) trial was a randomized, placebo-controlled, double-blind trial of calcium compared to placebo in OHCA.  COCA found no improvement in sustained ROSC but, rather, a trend towards harm for their primary outcome. Additionally, …

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Non-Sterile Gloves for Suturing Traumatic Lacerations?

Background: Traumatic lacerations presenting to the emergency department are, by definition, contaminated (ie non-sterile).  Standard management involves irrigation, local anesthesia, closure and tetanus update if required. The existing literature has never shown benefit to sterile gloves in these types of …

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Procedures and SkillsTrauma

REBEL Cast Ep111: The PREPARE II Trial – Fluid Bolus Prior to Intubation?

Background:  Some of the feared complications of endotracheal intubation include hypotension, cardiac arrest, and death (cardiovascular collapse).  These complications can result from numerous causes including medication-induced vasodilation and decreased venous return to the heart due to increased intrathoracic pressure from …

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Procedures and SkillsResuscitation

Topical TXA in Atraumatic Anterior Epistaxis Yet Again

Background: The use of topical tranexamic acid (TXA) for anterior epistaxis has been studied in many trials with conflicting results. The largest and most methodologically rigorous study to date on the use of topical TXA in epistaxis has been the …

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Head, Eye, Ear, Nose, and Throat