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Author: Salim Rezaie

REBEL Cast Ep 118: The PROCOAG Trial – 4F-PCC for Trauma Patients?

Background: Hemorrhage is the leading cause of mortality in trauma patients.  Interventions such as early application of hemorrhage control, tranexamic acid, reduction of crystalloid  fluid administration and balanced ratio blood product transfusion have improved many patients’ outcomes. However, mortality still …

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Trauma

Anaphylactic Shock

Anaphylactic Shock is an acute, life-threatening hypersensitivity disorder, with a generalized, rapidly evolving, multi-systemic allergic reaction (IgE-mediated disorder). If not treated rapidly can become fatal. Scott Weingart, MD put together  a manual titled the Resuscitation Crisis Manual, which in short, …

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Allergy and ImmunologyResuscitation

Adjunctive Methylene Blue in Septic Shock?

Background: Sepsis can induce numerous physiologic derangements.  At the most severe end, this includes endothelial dysfunction leading to increased vascular permeability, abnormal nitric oxide metabolism, and vasodilation (i.e. septic shock).  Judicious fluid resuscitation is indicated in patients with signs of …

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Infectious DiseaseResuscitation

Trauma Resuscitation Updates

I recently gave a talk on the initial management of trauma patients with hemorrhagic shock.  In the initial management of trauma resuscitation there are 4 key principles that should be followed: Control bleeding Restore tissue perfusion Minimize iatrogenic injury from …

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ResuscitationTrauma

REBEL Cast Ep116: The CLOVERS Trial – Restrictive vs Liberal Fluids in Sepsis-Induced Hypotension

Background: IV fluids are part of the standard resuscitation bundle in septic shock, however it is unclear if they provide a significant benefit. These patients can have a vasodilated vascular bed and the initial use of fluids is hypothesized to …

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Infectious DiseaseResuscitation

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