Archive

Rebel Category: REBEL EM

Fluid Administration in End-Stage Renal Disease for Severe Sepsis and Septic Shock by Shyam Murali, MD

Background: In end-stage renal disease (ESRD) patients on hemodialysis (HD), infection is the second most common cause of mortality after cardiovascular disease (Sarnik 2000). Because of the systemic inflammation and increased capillary permeability, septic patients are at significant risk for fluid ...

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Endocrine, Metabolic, Fluid, and ElectrolytesInfectious DiseaseResuscitation

Hydroxychloroquine is Ineffective for Post-Exposure Prophylaxis

Background: Despite the initial excitement around the use of chloroquine (CQ) and hydroxychloroquine (HCQ), there is mounting evidence that neither drug is effective in COVID-19 treatment. Laboratory studies have shown antiviral and immunomodulatory properties in vitro but these have not ...

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Infectious Disease

Convalescent Plasma Therapy for COVID-19: Hopeful Signals of Improvement

Background: Convalescent plasma therapy is not a new or novel therapeutic option.  It involves taking the plasma from patients who have recovered from an illness and using it to treat patients who currently have the same illness. This approach has ...

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Infectious Disease

COVID-19: Remdesivir RCT #3 (5d vs 10d)

Background: We have covered the two previous RCTs on remdesivir on REBEL EM (RCT #1 and RCT #2). In the first trial by Wang et al , there was no statically significant improvement in clinical outcomes, but, there were trends ...

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Infectious Disease

The FISH RCT: Surgical vs Non-Surgical Management of Displaced Humeral Shaft Fractures

Background: Humeral shaft fractures are commonly seen in the Emergency Department and emergency management is relatively straightforward: assess for other trauma, assess for radial nerve injury, analgesia, sling or functional bracing and follow up with orthopedics. However, there are debates ...

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Orthopedics

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