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The TASC Trial: Therapeutic vs Prophylactic Anticoagulation for Acute Chest Syndrome

In adults with sickle cell disease hospitalized for acute chest syndrome (ACS) without pulmonary artery macrothrombosis, does therapeutic-dose anticoagulation with tinzaparin shorten ACS duration compared with prophylactic-dose anticoagulation?

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Hematology and Oncology

REBEL MIND – Mastery Learning and Deliberate Practice

Welcome back to Rebel MIND, the podcast where we sharpen the person behind the practitioner. MIND stands for Mastering Internal Negativity during Difficulty. This series emphasizes productivity, provider performance, and team optimization to ensure we are at our best during ...

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Human BehaviorTeam Performance

MDCalc Wars: Massive Transfusion in Trauma – ABC vs. TASH

The ABC Score is a rapid, 4-variable bedside tool for immediate massive transfusion decisions — before labs are back; TASH provides a more precise probability estimate once labs and imaging are available

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ResuscitationTrauma
Healthcare team preparing for rapid sequence intubation with an endotracheal tube and oxygen mask, illustrating rocuronium vs succinylcholine for RSI, awareness, paralysis, and post-intubation sedation.

Rocuronium vs Succinylcholine for RSI: Awareness, Paralysis, and Post-Intubation Sedation

Does rocuronium delay post-intubation sedation and analgesia compared with succinylcholine after RSI? This REBEL EM post appraises a retrospective ED cohort study examining paralytic choice, analgosedation timing, and the risk of awareness during paralysis.

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Procedures and SkillsResuscitation
Nitrous oxide toxicity title image showing whippet canisters and a red balloon on a hospital stretcher

REBEL Core Cast—Nitrous Oxide Toxicity: Whippets and Neurologic Injury

Nitrous oxide, commonly known as “whippets,” is often perceived as harmless. However, frequent use can lead to functional vitamin B12 deficiency, subacute combined degeneration, and potentially permanent neurologic dysfunction. This review covers the pathophysiology, clinical presentation, diagnosis, and treatment of ...

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Toxicology
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