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OPTION Trial tenecteplase for non-LVO stroke (late window, CT perfusion selected)

The OPTION Trial: Late-Window TNK for Non-LVO Stroke

The OPTION trial evaluated IV tenecteplase (0.25 mg/kg) in CT perfusion–selected non-LVO ischemic stroke patients treated 4.5–24 hours after last-known-well. Tenecteplase improved excellent 90-day outcomes (mRS 0–1) but increased symptomatic intracranial hemorrhage, with the benefit–harm balance sensitive to outcome and ...

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Neurology

The EVERDAC Trial: Non-Invasive BP vs Arterial Lines in the Critically Ill

The EVERDAC trial sought to determine if managing shock with noninvasive brachial cuff monitoring is noninferior to early (<4 hours) arterial catheter placement

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CardiovascularResuscitation
Growth vs fixed mindset in medicine illustrated by evolving tree heads showing learning, development, and performance improvement in healthcare

REBEL MIND – Growth vs Fixed Mindset in Medicine

Mindset shapes everything we do in medicine—from how we teach and learn to how we show up for patients at the bedside. In this episode, we delve into how the mindset of clinicians can profoundly influence their performance, professional growth, ...

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Human BehaviorPsychiatry/Behavioral HealthTeam Performance
Minimalist comparison graphic of HAT vs SEDAN for estimating hemorrhage risk after stroke thrombolysis, featuring a grayscale brain, red lightning bolt, and labeled comparison circles.

MDCalc Wars: HAT vs SEDAN — Hemorrhage Risk After Stroke Thrombolysis

The HAT and SEDAN scores help estimate symptomatic intracranial hemorrhage risk after stroke thrombolysis. This comparison reviews what each tool measures, when to use them, and the key limitations clinicians should know.

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Neurology
Queen of Hearts playing card on a grayscale deck representing AI vs physicians in STEMI-equivalent and STEMI-mimic ECG interpretation

The Queen of Hearts Returns: AI vs Physicians in STEMI-Equivalent and STEMI-Mimic ECGs

STEMI-equivalent and STEMI-mimic ECGs are among the most difficult tracings to interpret. This study examines how Queen of Hearts AI performed against physicians when accuracy in cath lab activation decisions mattered most.

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Cardiovascular

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