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COVID-19 Update: The COVID-19 Pfizer Vaccine

Background: The COVID-19 Pfizer BNT162b2 vaccine, let’s just call it the COVID-19 Pfizer vaccine (so I don’t have to keep writing BNT162b2) is a novel mRNA vaccine developed to give immunity against the SARS CoV2 virus. It is synthesized mRNA packaged ...

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Infectious Disease

The 1st Community ECMO Program in the US

Background: In the US out-of-hospital cardiac arrest (OHCA) has an estimated survival rate of <10% overall, but slightly better survival rates with shockable rhythms of approximately 30% . A small proportion of these patients will have refractory VF/VT OHCA not ...

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Resuscitation

New and Interesting: Timolol Eyedrops to Treat Migraine Headaches

Background: Acute migraine headaches are a common presentation to emergency departments.  Treatment can be challenging: multiple medications are often required and allergies can limit options. Oral timolol maleate is approved by the FDA for migraine prophylaxis but is not typically ...

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Neurology

The ISARIC WHO Clinical Characterization Protocol: Risk Stratification of Patients Admitted to Hospital with COVID-19

Background: SARS-CoV-2 infection has resulted in a high mortality rate, with the majority of deaths resulting from respiratory failure. As waves of the pandemic continue to overwhelm healthcare systems throughout the world, a pragmatic risk stratification tool that would allow ...

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Infectious Disease

COVID-19 Update: The PlasmAr Trial – Convalescent Plasma vs Placebo

Background: Despite limited high-quality evidence, many institutions are currently using convalescent plasma therapy (CPT) in the treatment of COVID-19.  The majority of the evidence for CPT comes from observational studies lacking placebo arms (US Expanded Access Program). Convalescent plasma therapy ...

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Infectious Disease

BLAZE-1: COVID-19 Neutralizing Antibody (Bamlanivimab)

Background: Throughout the COVID19 pandemic, massive efforts have been invested on the research of effective therapeutics.  Much of the research looks at repurposing older treatments (i.e. antimalarial drugs, antiviral agents, interleukin blockers and convalescent plasma therapy).  There have been no ...

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Infectious Disease

Aromatherapy vs Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients

Background Information: Nausea and/or vomiting are chief complaints that account over 4 million emergency department (ED) visits each year.1 Multiple studies have shown aromatherapy in the form of isopropyl alcohol “prep” pads to be effective in postoperative nausea and vomiting.2,3 ...

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Abdominal and Gastrointestinal

REBEL Core Cast 45.0 – Mesenteric Ischemia

Take Home Points Be sure to consider mesenteric ischemia in any elderly patient with abdominal pain or lower gastrointestinal (GI) complaints.  Remember, the presentation can be tricky to find and they may have a reassuring abdominal exam. Ask about artherosclerotic ...

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Abdominal and Gastrointestinal

Vexed on Vaccines: Vaccine Hesitancy, Fact Immunity, and a Pandemic of Misinformation

It is no secret we are in the middle of a pandemic, the likes of which our generation has never seen. Every day, clinicians care for thousands of patients infected with SARS-CoV2. One sick person can infect many more without ...

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Infectious Disease

Adjunctive Pain Management of Renal Colic and Migraines

Background: Renal colic and migraine headaches are common emergency department presentations.  There are a wide range of medications available to treat pain from these disorders including opioids and non-steroidal anti-inflammatory drugs. Opioids have two major issues: dependency and side effects ...

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NeurologyRenal and Genitourinary
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