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Rebel Category: REBEL Crit

REBEL EM Useful Critical Care/ICU Stuff

I have started to split my time between the ED and ICU.  Obviously these two areas of clinical care have their similarities, but also have their differences. So I decided to create this post to put things that I have ...

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ResuscitationThoracic and Respiratory

TTM2: Hypothermia vs Normothermia for Out-of-Hospital Cardiac Arrest

Background Information: Hypothermia was first introduced in 2002 by two studies, Bernard et al and The Hypothermia After Cardiac Arrest (HACA) trial.1,2 The latter, although a small trial, showed improved neurologic outcomes at six months when patients were cooled to ...

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CardiovascularNeurologyResuscitation

The MENDS2 Trial: Dexmedetomidine vs Propofol for Sedation

Background: In patients requiring mechanical ventilation, sedative medications are used for patient comfort and safety.  However, these medications can also lead to brain dysfunction (i.e. delirium or coma) and long-term cognitive impairment. Currently, the Society of Critical Are Medicine ...

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Thoracic and Respiratory

The VICTAS Trial: How Many More RCTs do we Need on the Metabolic Cocktail in Sepsis?

Background: Since the publication of the before and after Marik trial published in 2016, there have been six randomized clinical trials trying to answer the question of the utility of the metabolic cocktail (Vitamin C, thiamine, and hydrocortisone) in ...

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Infectious Disease

The HOT-ICU Trial: Lower vs Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

Background: Though oxygen is fundamental for life, supra-physiological levels can be deleterious. Several randomized controlled trials and meta-analyses have been conducted in the critically ill to determine whether a conservative oxygenation approach compared to a liberal oxygenation approach is beneficial. ...

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Thoracic and Respiratory
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