The Novel Coronavirus 2019, was first reported on in Wuhan, China in late December 2019.  The outbreak was declared a public health emergency of international concern in January 2020 and on March 11th, 2020, the outbreak was declared a global pandemic.  The spread of this virus is now global with lots of media attention.  The virus has been named SARS-CoV-2 and the disease it causes has become known as coronavirus disease 2019 (COVID-19). This new outbreak has been producing lots of hysteria and false truths being spread, however the data surrounding the biology, epidemiology, and clinical characteristics are growing daily, making this a moving target.

REBEL COVID-19

will serve as a summary of what is currently known, how to screen, when to test, and how to prevent spread, and any new data/information on COVID-19.

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  • REBEL Covid-19
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  • REBEL Covid-19

GLUCOCOVID: A Controlled Trial of Methylprednisolone in COVID-19 Pneumonia

Background Information: The use of corticosteroids in patients with pneumonia secondary to COVID-19 has been a controversially hot topic, particularly early on in the pandemic. Prior evidence seen in Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Respiratory Syndrome have …

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Infectious DiseaseThoracic and Respiratory

Data from Israel on the BNT162b2 (Pfizer) mRNA COVID-19 Vaccine

Background: COVID-19 vaccination is ramping up both in the US as well as throughout the world. Randomized clinical trials looking at the efficacy of the mRNA vaccines demonstrated 94% to 95% reductions in symptomatic cases (Polack 2020). Randomized clinical trials …

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Infectious Disease

Data from Israel in Health-Care Workers Vaccinated with 1st Dose of the Pfizer COVID-19 Vaccine

Background: Israel has succeeded in ramping up its vaccination program faster than any nation in the world. In December 2020, Israel began a national immunization campaign prioritizing health-care workers. In the original clinical trial data, the Pfizer vaccine was estimated …

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Infectious Disease

Be Heard In a Respirator Mask

Background: A major challenge during the COVID pandemic is balancing personal protection and communication. Being heard while wearing a surgical mask or N95 isn’t too much of a challenge, communication can be significantly impaired while wearing a respirator mask. There …

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Resuscitation

COVID-19 Update: Convalescent Plasma Therapy & Anticoagulation

Background: Medicine by press release has been an unfortunate reality of the COVID-19 pandemic.  This is not the standard many physicians would use for medical decision making, but one many of us have had to face; what do I do …

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Infectious Disease

COVID-19 Update: Time to Let Go of Convalescent Plasma Therapy

Background: Early observational studies led to the Emergency Use Authorization (EUA) for convalescent plasma therapy (CPT) in the US in August 2020 for the treatment of COVID-19. Data from the RECOVERY trial, the largest clinical trial on COVID-19 treatments was …

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Infectious Disease

Vitamin D Does Not Decrease Hospital Length of Stay in COVID-19

Background: As the COVID pandemic rages on, we continue to search for treatments to help combat the disease. Severely ill patients commonly have low levels of vitamin D and it has been suggested that optimal levels of Hydroxyvitamin D may …

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Infectious Disease

The STOIC Trial: Inhaled Budesonide in the Treatment of Early COVID-19

Background: COVID-19 typically starts as a mild illness that progresses over several days. Most treatment interventions for COVID-19 are focused on hospitalized patients who have progressed past this mild illness.  Monoclonal antibodies have been heavily touted in this role for …

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Does D Stand for Decrease Deterioration + Death? – The Jury is Out for Vitamin D in COVID

Update: This article was removed from the Lancet server on February 19th, 2021 (Link) Background: Vitamin D deficiency is common amongst critically ill patients and there has been ample speculation about a possible role for supplementation (with calcifediol) in the …

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Infectious Disease

REBEL Cast Ep95: Colchicine in COVID (COLCORONA)? Don’t Believe the Hype.

Background: Science by press release. Not the way any of us would choose to operate but, the COVID pandemic has made this a reality. It’s vital that we understand that while pharmaceutical companies have a responsibility to release this information, …

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Infectious Disease

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