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Tag: Tranexamic Acid

Meta-Analysis on Topical TXA for Epistaxis

Background Information: Epistaxis management in the emergency department has historically included topical vasoconstrictors, local anesthetics such as oxymetazoline and phenylephrine and topical fibrinolytic agents such as Tranexamic Acid (TXA). When these topical agents fail, packing, chemical cauterization or surgical ligation …

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Head, Eye, Ear, Nose, and ThroatProcedures and SkillsResuscitation

IM Administration of Tranexamic Acid

Background: We have covered tranexamic acid (TXA) on this blog in several posts. Its use has been studied for everything that bleeds from abnormal uterine bleeding to GI hemorrhage and from multisystem trauma to intracranial hemorrhage. While over the past few …

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Trauma

Should we Rubber STAAMP Prehospital TXA?

Background: It almost seems that when it comes to the use of the antifibrinolytic agent tranexamic acid (TXA) in trauma, one argument has just been completed and another one comes up right behind it. Let’s take a step back. Most …

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Trauma

Out-Of-Hospital TXA for TBI

Background: The CRASH-2 trial, published in 2010, showed a survival benefit for patients with traumatic hemorrhage who received TXA compared to placebo.  TXA has become standard practice in many settings as a result of this data. However, patients with significant …

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Trauma

REBEL Cast Ep85: The HALT-IT Trial – TXA in Acute GI Bleeds

Background: Acute gastrointestinal bleeding (GIB) is a common diagnosis dealt with by emergency clinicians.  Definitive therapy for acute GIB often includes endoscopy or surgery. However, there is a myriad of pharmaceutical options (i.e. PPI, Somatostatin Analogues, Antibiotics, etc.) as well …

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Abdominal and Gastroinstestinal

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