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Rebel Category: REBEL EM

US Expanded Access Program: Convalescent Plasma, Mortality, and COVID-19

Background: Convalescent plasma therapy (CPT) is not a novel treatment modality.  It has been used in other illnesses such as SARS, MERS, and Ebola with variable results. The theory behind CPT is to take antibody rich blood from patients who ...

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Infectious Disease

The ALIC4E Trial: Oseltamivir + Usual Care vs Usual Care Alone

Background: Previous evidence has found that oseltamivir reduces median time to alleviation of influenza symptoms over placebo by about 1 day.  The benefits were greater when treatment was initiated within 24 to 48 hours of symptoms onset. Many previous trials ...

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Infectious Disease

Remdesivir in Moderate COVID-19

Background: There are three randomized clinical trials now published on remdesivir in the treatment of COVID-19 pneumonia (RCT 1, RCT 2, & RCT 3). The 1st trial, performed in China, was terminated early due the lack of patients to enroll ...

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Infectious Disease

It’s Raining Steroids in COVID-19: REMAP-CAP, CoDEX, & CAPE COVID

Background: Over the past few years, corticosteroids have gained traction in the treatment of patients with ARDS and septic shock.  Trials such as APROCCHSS and ADRENAL have shown that the use of corticosteroids is associated with more rapid resolution of ...

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Infectious Disease

The THALES Trial: Ticagrelor and Aspirin vs Aspirin Alone in Acute Ischemic Stroke or TIA

Background: The risk of a subsequent ischemic stroke in the first few months after an acute ischemic stroke or transient ischemic attack is approximately 5 to 10%. In these patients Aspirin has been used to prevent secondary ischemia, and trials ...

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Neurology
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