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Medical Category: Infectious Disease

The ORANGES Trial: Why You Can’t Just Read the Abstract

Background: The cornerstones of sepsis management continues to include early identification, early appropriate empiric antibiotics, definitive source control, and vasopressors to support end organ perfusion. There have been multiple studies looking at the co-administration of hydrocortisone, ascorbic acid, and thiamine ...

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Infectious Disease

COVID-19 Treatment Update: Can We Just Stop Wasting Time on Hydroxychloroquine

Background: Hydroxychloroquine (HCQ) is an antimalarial and immunomodulatory drug that is postulated to exert an antiviral effect by increasing intracellular pH resulting in decreased viral binding at the ACE2 receptor. Azithromycin is a macrolide antibiotic that also has anti-inflammatory and ...

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Infectious Disease

Spinal Epidural Abscess (SEA)

Definition: Suppurative infection enclosed within the epidural space Epidemiology Incidence: 2-3 cases per 10,000 hospitalized patients (Sendi 2008). Rate is increasing given the rise in number of spinal procedures and anesthesia techniques Mortality is low at 5%, however, if untreated ...

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Infectious DiseaseNeurology

The RECOVERY Trial: Dexamethasone for COVID-19?

Background: We have been in need of a sign of hope in the fight against SARS-CoV-2 as it runs from city to city overwhelming health systems.  The majority of patients will be either asymptomatic or have only mild disease.  These ...

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Infectious Disease

Fluid Administration in End-Stage Renal Disease for Severe Sepsis and Septic Shock by Shyam Murali, MD

Background: In end-stage renal disease (ESRD) patients on hemodialysis (HD), infection is the second most common cause of mortality after cardiovascular disease (Sarnik 2000). Because of the systemic inflammation and increased capillary permeability, septic patients are at significant risk for fluid ...

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Endocrine, Metabolic, Fluid, and ElectrolytesInfectious DiseaseResuscitation

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