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Clinical Conundrum: How Effective is Oseltamivir in Influenza?

Annual influenza cases exceed one billion worldwide, with the vast majority of patients experiencing mild to moderate severity of illness. This massive health burden explains the extensive research into antivirals, including oseltamivir (Tamiflu). Initial studies supported the utility of oseltamivir ...

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Infectious DiseaseThoracic and Respiratory

REBEL Core Cast 147.0–Ventilators Part 5: Key Mechanical Ventilator Pressures & Definitions Made Simple

This episode reviews essential ventilator pressures and how to interpret them during ICU rounds.

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Thoracic and Respiratory

Is Abelacimab the Next Step in AF Anticoagulation? Early Signals and Remaining Questions

Antithrombotic therapy is a cornerstone in the treatment of atrial fibrillation (AFib), though it carries a significant risk of bleeding. While Vitamin K antagonists (VKAs), the oldest anticoagulants, were largely supplanted by direct oral anticoagulants (DOACs) following trials like ARISTOTLE ...

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Cardiovascular

Clinical Conundrum: Pregnant and Puking: What’s Safe and Effective in the ED?

Nausea with or without vomiting is very common in early pregnancy, affecting approximately 70% of pregnancies (Maisal 2012). Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnancy that can lead to significant maternal dehydration, electrolyte abnormalities, and ...

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Obstetrics and Gynecology

REBEL Core Cast 146.0–Ventilators Part 4: Setting up the Ventilator

Ventilator management can feel overwhelming—there are so many knobs to turn, numbers to watch, and changes to make. But before adjusting any settings, it’s crucial to understand why the patient is in distress in the first place, because the right ...

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Thoracic and Respiratory

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