The Novel Coronavirus 2019, was first reported on in Wuhan, China in late December 2019.  The outbreak was declared a public health emergency of international concern in January 2020 and on March 11th, 2020, the outbreak was declared a global pandemic.  The spread of this virus is now global with lots of media attention.  The virus has been named SARS-CoV-2 and the disease it causes has become known as coronavirus disease 2019 (COVID-19). This new outbreak has been producing lots of hysteria and false truths being spread, however the data surrounding the biology, epidemiology, and clinical characteristics are growing daily, making this a moving target.

REBEL COVID-19

will serve as a summary of what is currently known, how to screen, when to test, and how to prevent spread, and any new data/information on COVID-19.

  • All Categories
  • Cardiovascular
  • Endocrine, Metabolic, Fluid, and Electrolytes
  • Hematology and Oncology
  • Infectious Disease
  • Neurology
  • Pediatrics
  • Procedures and Skills
  • Resuscitation
  • Thoracic and Respiratory
All Categories
  • All Categories
  • Cardiovascular
  • Endocrine, Metabolic, Fluid, and Electrolytes
  • Hematology and Oncology
  • Infectious Disease
  • Neurology
  • Pediatrics
  • Procedures and Skills
  • Resuscitation
  • Thoracic and Respiratory

COVID-19 Update: The ChAdOx1 (AstraZeneca) COVID-19 Vaccine

Background Information: With rising cases, an increasing death toll, and a significant strain on hospital systems globally, the COVID-19 pandemic seemed to have no end in sight. The aggressive pursuit of a vaccine has led to multiple clinical trials starting before …

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Infectious Disease

REBEL Cast Ep93: COVID-19 – A Follow Up on Not Intubating Early and ARDSnet

Back in April 2020, on REBEL Cast episode 79 we sat down to discuss COVID-19.  Specifically, we focused on not intubating patients early and why ARDSnet may not be the best ventilator paradigm for patients with COVID-19.  By popular demand, …

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Infectious Disease

COVID-19 Update: Ivermectin

Background: Throughout the COVID-19 pandemic, numerous therapeutic agents have been repurposed and applied empirically and within clinical trials. Prophylactic medications for COVID-19 could have a huge benefit, but studies to date haven’t panned out. Initially many therapeutic medications were used late in …

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Infectious Disease

COVID-19 Update: The COVID-19 Pfizer Vaccine

Background: The COVID-19 Pfizer BNT162b2 vaccine, let’s just call it the COVID-19 Pfizer vaccine (so I don’t have to keep writing BNT162b2) is a novel mRNA vaccine developed to give immunity against the SARS CoV2 virus. It is synthesized mRNA packaged …

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Infectious Disease

The ISARIC WHO Clinical Characterization Protocol: Risk Stratification of Patients Admitted to Hospital with COVID-19

Background: SARS-CoV-2 infection has resulted in a high mortality rate, with the majority of deaths resulting from respiratory failure. As waves of the pandemic continue to overwhelm healthcare systems throughout the world, a pragmatic risk stratification tool that would allow …

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Infectious Disease

COVID-19 Update: The PlasmAr Trial – Convalescent Plasma vs Placebo

Background: Despite limited high-quality evidence, many institutions are currently using convalescent plasma therapy (CPT) in the treatment of COVID-19.  The majority of the evidence for CPT comes from observational studies lacking placebo arms (US Expanded Access Program). Convalescent plasma therapy …

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Infectious Disease

BLAZE-1: COVID-19 Neutralizing Antibody (Bamlanivimab)

Background: Throughout the COVID19 pandemic, massive efforts have been invested on the research of effective therapeutics.  Much of the research looks at repurposing older treatments (i.e. antimalarial drugs, antiviral agents, interleukin blockers and convalescent plasma therapy).  There have been no …

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Infectious Disease

Vexed on Vaccines: Vaccine Hesitancy, Fact Immunity, and a Pandemic of Misinformation

It is no secret we are in the middle of a pandemic, the likes of which our generation has never seen. Every day, clinicians care for thousands of patients infected with SARS-CoV2. One sick person can infect many more without …

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Infectious Disease

COVID-19 Update: An Interesting Study on Serotonin Antagonism

Background: We have tried to decrease the number of updates on COVID-19, as I am sure everyone is getting tired of all the trials coming out on this.  I know I am exhausted just reading through everything.  However, every so …

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Infectious Disease

The DANMASK-19 Trial: Masks Not Effective to Prevent COVID-19? Not So Fast!!!

Background: Face masks can reduce transmission of respiratory viruses by both being a potential physical barrier and by reducing droplet transmission.  Additionally, the presence of a mask reduces the users frequency of touching their face which may also reduce transmission.  …

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Infectious Disease

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