Author: Anand Swaminathan

REBEL Core Cast 105.0 – Methylxanthine Toxicity

Take Home Points Methylxanthines are a drug class that includes caffeine, theophylline, and theobromine. The three main mechanisms that account for the clinical presentation of methylxanthine toxicity are: catecholamine release, adenosine antagonism, and phosphodiesterase inhibition. Beta agonism will lead to …

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Peri-Intubation Hypotension – Dose Induction Dose Matter?

Background: Rapid Sequence Intubation (RSI) is a procedure fraught with potential complications including hypotension which, in turn, can result in cardiovascular collapse. While there are numerous potential causes of hypotension peri-RSI, induction medications represent an important, modifiable variable. Over the …

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Procedures and Skills

The COVID-OUT Trial: Does Metformin Reduce the Risk of Long COVID?

Background: The COVID-19 pandemic has been the focus of massive research efforts over the last three years. Our understanding of the disease and effective treatments to reduce mortality have progressed rapidly during this time. However, the medical community is only …

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Infectious Disease

Rethinking the Role of TXA: Are We Asking Too Much?

Background: Injuries are a major cause of death worldwide. Hemorrhage accounts for about 1/3 of all trauma deaths and as such, it should be our goal to find treatments to decrease death from hemorrhage. Our bodies have a finely tuned …

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REBEL Core Cast 103.0 – Caustic Ingestions

Take Home Points Caustics are substances that injure tissue upon physical contact. Caustic potential is not purely a function of pH. The decision to admit is dependent on the history and physical. Vomiting, drooling, and stridor are concerning. Stridor alone …

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Abdominal and GastroinstestinalToxicology