Archive

Author: Salim Rezaie

Let’s Get Our ACTS Together: The Metabolic Cocktail and Septic Shock Again

Background: Though it’s been stated numerous times on this blog, it bears repeating: the pillars of sepsis care remain early identification of sepsis, early appropriate empiric antibiotics, source control, and supportive care. The focus should be on getting the basics …

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Infectious Disease

Remdesivir in Moderate COVID-19

Background: There are three randomized clinical trials now published on remdesivir in the treatment of COVID-19 pneumonia (RCT 1, RCT 2, & RCT 3). The 1st trial, performed in China, was terminated early due the lack of patients to enroll …

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Infectious Disease

It’s Raining Steroids in COVID-19: REMAP-CAP, CoDEX, & CAPE COVID

Background: Over the past few years, corticosteroids have gained traction in the treatment of patients with ARDS and septic shock.  Trials such as APROCCHSS and ADRENAL have shown that the use of corticosteroids is associated with more rapid resolution of …

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Infectious Disease

GRECCO-19: Colchicine for COVID-19?

Background: The most severe SARS-CoV-2 infections result in an intense inflammatory response which can lead to acute lung injury and/or acute respiratory distress syndrome.  Theoretically, potential treatments for severe disease should have anti-inflammatory action without substantial side effects. One candidate …

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Infectious Disease

The VEINART Trial: VBG vs ABG

Background: Patients coming to the ED frequently have several interventions performed in their evaluation and management.  Blood draws, for the most part, are venous. Occasionally, however, arterial sampling is used to gauge acid-base status, PaO2, PaCO2, lactate etc.  This is …

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Procedures and Skills

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