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Medical Category: Thoracic and Respiratory

The Pneumonia Short Treatment Trial: Antibiotic Treatment for 3 days vs 8 days

Background: In 2019 the World Health Organization listed “Antimicrobial Resistance” as a top 10 threat to global health. This was echoed in a 2021 document. [WHO 2019, WHO 2021] The classic medical teaching regarding antimicrobial therapy pushed for longer treatment …

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Infectious DiseaseThoracic and Respiratory

The MENDS2 Trial: Dexmedetomidine vs Propofol for Sedation

Background: In patients requiring mechanical ventilation, sedative medications are used for patient comfort and safety.  However, these medications can also lead to brain dysfunction (i.e. delirium or coma) and long-term cognitive impairment. Currently, the Society of Critical Are Medicine [2] …

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Thoracic and Respiratory

GLUCOCOVID: A Controlled Trial of Methylprednisolone in COVID-19 Pneumonia

Background Information: The use of corticosteroids in patients with pneumonia secondary to COVID-19 has been a controversially hot topic, particularly early on in the pandemic. Prior evidence seen in Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Respiratory Syndrome have …

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Infectious DiseaseThoracic and Respiratory

REBEL Review 101: Richmond Agitation-Sedation Scale (RASS)

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REBEL Reviews

The HOT-ICU Trial: Lower vs Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

Background: Though oxygen is fundamental for life, supra-physiological levels can be deleterious. Several randomized controlled trials and meta-analyses have been conducted in the critically ill to determine whether a conservative oxygenation approach compared to a liberal oxygenation approach is beneficial. …

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Thoracic and Respiratory

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