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Medical Category: Thoracic and Respiratory

The SAFER Trial: Pediatric CAP – Amoxicillin 5 days vs 10 days

Background: The evidence supporting the use of a 10-day course of high-dose amoxicillin to treat community-acquired pneumonia (CAP) in pediatric patients is weak. In addition, medicine is trending towards shorter courses of antibiotics when clinically appropriate. REBEL EM covered a similar …

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Infectious DiseaseThoracic and Respiratory

REBEL Cast Ep99: The INTUBE Study –  Adverse Peri-Intubation Events in the Critically Ill

Background: It’s no surprise that unplanned, emergency intubations are significantly different from intubations in the operating room (OR). Unplanned intubations on the floors and in the ED and ICU settings are highly unlikely to be “physiologically optimized:” they have underlying …

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Procedures and SkillsThoracic and Respiratory

Dexamethasone vs Methylprednisolone in ICU Patients with COVID19

Background Information: Over one year into the pandemic many therapies to treat COVID-19 have targeted innumerable aspects of the virus. Most recently, the use of corticosteroids to treat the virus’ excessive inflammatory effects has become the front and center of …

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Endocrine, Metabolic, Fluid, and ElectrolytesInfectious DiseaseThoracic and Respiratory

The Pneumonia Short Treatment Trial: Antibiotic Treatment for 3 days vs 8 days

Background: In 2019 the World Health Organization listed “Antimicrobial Resistance” as a top 10 threat to global health. This was echoed in a 2021 document. [WHO 2019, WHO 2021] The classic medical teaching regarding antimicrobial therapy pushed for longer treatment …

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Infectious DiseaseThoracic and Respiratory

The MENDS2 Trial: Dexmedetomidine vs Propofol for Sedation

Background: In patients requiring mechanical ventilation, sedative medications are used for patient comfort and safety.  However, these medications can also lead to brain dysfunction (i.e. delirium or coma) and long-term cognitive impairment. Currently, the Society of Critical Are Medicine [2] …

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Thoracic and Respiratory

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