Archive

Medical Category: Infectious Disease

REBEL Cast Ep 61: Diagnostic Questions in Urinary Tract Infections in the Elderly

Introduction: Beyond the Data The evolution from eminence-based to evidence-based care has come to define bedside emergency medicine, with rigorous skepticism and scholarly consideration accelerated by the power of global connectivity. Where anecdote and opinion once drove therapy, clinicians now …

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Infectious Disease

Early Sepsis Screening in the Emergency Department

Background Information: Sepsis is a complex syndrome frequently encountered in the ED. This infection-triggered, multifaceted disorder of life-threatening organ dysfunction is due to the body’s dysregulated response to pathologic and biochemical abnormalities.2-4 There has been significant debate regarding the use of …

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Infectious Disease

Baloxavir (Xofluza), a New Influenza Anti-Viral Medication is FDA Approved, But Does it Work?

Background: On October 24th, 2018, Roche, the maker of oseltamivir, announced that the US Food and Drug Administration (FDA) approved Xofluza (baloxavir marboxil) for the treatment of acute, uncomplicated influenza in people 12 years of age and older. Historically, there …

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Infectious Disease

The Tamiflu Debacle

Background:  Oseltamivir (Tamiflu), a neuraminidase inhibitor, was approved by the FDA in 1999.  The majority of the evidence supporting the use of the medication came from trials funded by Roche, the maker of the drug. Safety issues with the drug …

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Infectious Disease

(Dis)Utility of Procalcitonin in Lower Respiratory Tract Infections (ProACT Trial)

Background: The mis- and overuse of antibiotics continues to be a growing problem in medicine; the results of which are increased health-care costs, increased antibiotic resistance and, ultimately, patient harm. Unnecessary antibiotics are particularly prevalent in the treatment of lower …

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Infectious Disease

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