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- Allergy and Immunology
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- Endocrine, Metabolic, Fluid, and Electrolytes
- Environmental
- Ethical and Legal
- Head, Eye, Ear, Nose, and Throat
- Hematology and Oncology
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- Infectious Disease
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Heads Up! There is No Association with Improved Outcomes for Head Up CPR: Why We Must Read Past the Abstract
Background: There are only two interventions that have been proven in the medical literature to improved outcomes in cardiac arrest: high-quality CPR and early defibrillation. Over the years, we as a scientific community have worked extensively to find other interventions ...
The ADVOR Trial: Acetazolamide in Acute Decompensated Heart Failure
Background: Patients presenting with acute exacerbations of congestive heart failure are frequently treated with intravenous loop diuretics. Despite being treated with loop diuretics, the problem is many are discharged from the hospital with residual clinical signs of volume overload despite ...
The REVIVED Trial: PCI in Patients with Severe Ischemic Left Ventricular Systolic Dysfunction?
Background: Coronary artery disease can result in hibernating myocardium (chronic myocardial contractile dysfunction) due to ischemia. The theory is that there is reduced coronary blood flow and increased myocardial demand resulting in impaired contractility. Whether reversal of myocardial hibernation by ...
REBEL Cast Ep112: The Pre-AeRATE Trial – HFNC vs NC for RSI
Background: Hypoxemia is a commonly encountered adverse event during rapid sequence intubation (RSI) in the ED. Critically ill patients in the ED often have a lack of physiologic reserve, decreased cardiac output, increased shunting, and reduced pulmonary reserves. Therefore, a ...
The BOX Trial: BP & O2 Targets in Comatose Survivors of Cardiac Arrest
Background: Hypoxemia and hypoperfusion are important factors in outcomes after ROSC. While hypoxemia (SpO2 <90%) is clearly deleterious, it is unclear if hyperoxia is beneficial. Recent studies on patients requiring critical care have demonstrated that hyperoxia is harmful and instead ...
COCA Trial Follow-Up: Calcium vs Placebo on Long-Term Outcomes of OHCA
Background: The Calcium for Out-of-Hospital Cardiac Arrest (COCA) trial was a randomized, placebo-controlled, double-blind trial of calcium compared to placebo in OHCA. COCA found no improvement in sustained ROSC but, rather, a trend towards harm for their primary outcome. Additionally, ...
The EvK Trial: Ketamine vs Etomidate for Rapid Sequence Intubation
Background: The use of ketamine and etomidate for induction in rapid sequence intubation is heavily debated. The Ketased Trial (Jabre 2009) reported no significant difference between the two induction agents. However, recently the National Emergency Airway Registry reported ketamine is ...
Non-Sterile Gloves for Suturing Traumatic Lacerations?
Background: Traumatic lacerations presenting to the emergency department are, by definition, contaminated (ie non-sterile). Standard management involves irrigation, local anesthesia, closure and tetanus update if required. The existing literature has never shown benefit to sterile gloves in these types of ...
The DINAMO Study: Efficacy and Safety of Non-Antibiotic Outpatient Treatment in Mild Acute Diverticulitis
The DINAMO Study: Efficacy and Safety of Non-Antibiotic Outpatient Treatment in Mild Acute Diverticulitis James C. Fletcher, MD, FACEP and Nicholas Slattery, MD Background: Diverticulitis is a common finding amongst Emergency Department patients, accounting for more than 360,000 visits in ...
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