Archive

Author: Mark Ramzy

SCOPE-DKA: Normal Saline vs Plasmalyte in Severe DKA

Background Information:  Diabetic Ketoacidosis (DKA) is a life-threatening complication of diabetes that we frequently encounter in both the emergency department (ED) and intensive care unit (ICU). While intravenous fluid replacement remains one of several cornerstones of therapies, much debate exists ...

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Endocrine, Metabolic, Fluid, and ElectrolytesResuscitation

DoReMi Trial: Milrinone vs Dobutamine for Treatment of Cardiogenic Shock

Background Information: The management of patients in cardiogenic shock is often multifactorial, consisting of mechanical circulatory support, vasopressors and inotropes. While the latter two are the foundation of therapy, the literature is scarce on whether milrinone or dobutamine will be more ...

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CardiovascularResuscitation

TTM2: Hypothermia vs Normothermia for Out-of-Hospital Cardiac Arrest

Background Information: Hypothermia was first introduced in 2002 by two studies, Bernard et al and The Hypothermia After Cardiac Arrest (HACA) trial.1,2 The latter, although a small trial, showed improved neurologic outcomes at six months when patients were cooled to ...

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CardiovascularNeurologyResuscitation

External Validation of the Canadian Syncope Risk Score

Background Information: The Canadian Syncope Risk Score (CSRS) is one of several clinical decision tools used in the emergency department (ED) following a syncopal episode. (Figure 1) It was derived from one of the largest datasets currently available and its ...

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Cardiovascular

Dexamethasone vs Methylprednisolone in ICU Patients with COVID19

Background Information: Over one year into the pandemic many therapies to treat COVID-19 have targeted innumerable aspects of the virus. Most recently, the use of corticosteroids to treat the virus’ excessive inflammatory effects has become the front and center of ...

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Endocrine, Metabolic, Fluid, and ElectrolytesInfectious DiseaseThoracic and Respiratory

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