Archive

Tag: COVID-19

SSRIs and COVID-19

Background: The effects of the COVID-19 pandemic have been devastating. Given the novelty of the virus, only a few effective treatments have emerged to decrease mortality from SARS-CoV-2 infection. The morbidity and mortality of SARS-CoV-2 is thought to be due ...

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Infectious Disease

The INSPIRATION Trial: Intermediate Dose Anticoagulation in Critically Ill Patients with COVID-19

Background: COVID-19 infection increases the risk of thrombosis due to multiple factors.(Rico-Mesa, 2020). Over the last 2 years, researchers have published 12 RCTs investigating various anticoagulation strategies among patients diagnosed with COVID-19 in multiple clinical settings. To date, only a multiplatform ...

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CardiovascularHematology and OncologyInfectious DiseaseThoracic and Respiratory

The ACTION Trial: DOACs in Hospitalized Patients with COVID-19

Background: Patients hospitalized with COVID-19 are at increased risk for both arterial and venous thromboembolic disease. Multiple recent trials have investigated the efficacy of therapeutic or standard prophylactic anticoagulation in preventing thrombotic complications among patients with COVID-19 in a variety ...

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CardiovascularInfectious DiseaseThoracic and Respiratory

The MICHELLE Trial: Anticoagulation Post-Discharge in Patients Hospitalized Secondary to COVID-19

Background: Patients diagnosed with COVID-19 have an increased risk of thromboembolic events, including pulmonary embolism and deep vein thrombosis (DVT). In addition, COVID-19 patients with increased coagulation parameters such as D-dimer, fibrin degradation products, prothrombin time, and activated partial thromboplastin ...

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CardiovascularHematology and OncologyInfectious DiseaseThoracic and Respiratory

The MOVe-Out Trial: Molnupiravir – Oral Antivirals for Management of Covid-19?

Background: On December 23, 2021, the FDA granted molnupiravir emergency use authorization for the treatment of patients with Covid-19. Molnupiravir is a nucleoside analog that inhibits SARS-CoV-2 replication and triggers viral RNA mutagenesis. Until the release of oral antivirals, clinicians ...

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