Archive

Tag: COVID-19

The HEP-COVID Trial: Therapeutic Anticoagulation in Non-Critically Ill COVID-19 Patients

Background: Patients with COVID-19 are at increased risk from thromboembolic phenomena. Patient-specific factors such as comorbidities and immobility have been linked to thrombosis. Disease-specific factors such as virus-induced endothelial changes and cytokine storm may also be triggers. Furthermore, patients with elevated …

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Hematology and OncologyInfectious DiseaseThoracic and Respiratory

REBEL Cast Ep103: Outpatient COVID-19 Therapy

I was fortunate enough to record a podcast on Rob Orman’s, Stimulus podcast on Oct 14th, 2021.  We both felt it was an important enough topic that we should post it on both his and my site.  The treatment of …

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Infectious Disease

The DisCoVeRy Trial: Remdesivir in COVID-19 – An Expensive Version of Tamiflu?

Background: Since the beginning of the pandemic, hundreds of trials have been  performed looking at medications with the potential to be repurposed for use against COVID19. To date, no antiviral medications directed at SARS-CoV-2 have shown any convincing evidence of …

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Infectious Disease

The TOGETHER Trial: COVID-19 and Fluvoxamine Take Two

Background: Despite having a safe and effective set of vaccines for COVID-19, there have been some low resource countries in which it has been very challenging in getting the vaccine allocated.  Therefore, identifying an inexpensive, widely available, and effective therapy …

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Awake Proning for COVID-19 Acute Hypoxemic Respiratory Failure

Background: Awake prone positioning was an intervention adopted early in the COVID-19 pandemic for patients with hypoxemic respiratory failure.  Unfortunately, many early trials were not powered to show improvements in oxygenation, escalation of respiratory support, or mortality. The one meta-analysis …

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ResuscitationThoracic and Respiratory

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