Background: Vitamin C dissociates to ascorbate at physiological pH and is not organically synthesized by the human body. Vitamin C can function as an antioxidant and may mitigate endothelial oxidative stress in sepsis. (Amrein 2018) A small, single-center, before-and-after study ...
Background: There are only two interventions that have been proven in the medical literature to improved outcomes in cardiac arrest: high-quality CPR and early defibrillation. Over the years, we as a scientific community have worked extensively to find other interventions ...
Background: Hypoxemia and hypoperfusion are important factors in outcomes after ROSC. While hypoxemia (SpO2 <90%) is clearly deleterious, it is unclear if hyperoxia is beneficial. Recent studies on patients requiring critical care have demonstrated that hyperoxia is harmful and instead ...
Background: The Calcium for Out-of-Hospital Cardiac Arrest (COCA) trial was a randomized, placebo-controlled, double-blind trial of calcium compared to placebo in OHCA. COCA found no improvement in sustained ROSC but, rather, a trend towards harm for their primary outcome. Additionally, ...
Background: The use of ketamine and etomidate for induction in rapid sequence intubation is heavily debated. The Ketased Trial (Jabre 2009) reported no significant difference between the two induction agents. However, recently the National Emergency Airway Registry reported ketamine is ...
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