Archive

Medical Category: Neurology

Validation of the Ottawa Subarachnoid Hemorrhage Rule in Patients With Acute Headache

Background: The assessment and management of the acute onset headache from the perspective of the emergency department is a point of contention and discussion commonly faced by emergency providers.  The Ottawa Subarachnoid Hemorrhage Rule is a clinical decision making instrument that ...

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Neurology

PRISMS Trial: Alteplase vs. Aspirin in Minor Stroke

Background: Despite serious concerns about the role of alteplase in the management of acute ischemic stroke including, but not limited to, significant conflicts of interest, unbalanced baseline patient characteristics, systematic devaluation of contrary data, lack of reproduced benefit and low ...

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Neurology

TICH-2: TXA for Spontaneous ICH?

Background: Spontaneous, non-traumatic intracerebral hemorrhage, is one of the only stroke subtypes without a proven treatment. It is not as common as ischemic stroke, representing up to 20% of all strokes, but it accounts for almost half of all stroke deaths worldwide.  ...

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Neurology

Tenecteplase versus Alteplase before Endovascular Therapy for Ischemic Stroke (EXTEND-IA TNK)

Background: Alteplase is a tissue plasminogen activator that is approved for use prior to thrombectomy in ischemic strokes with the goal of reperfusion to ischemic areas of the brain. Tenecteplase is a recombinant enzyme derived from alteplase that is more ...

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Neurology

Cauda Equina Syndrome

Definition: Syndrome characterized by dysfunction of multiple lumbar and sacral nerve roots in the lumbar vertebral canal due to compression Anatomy The spinal cord terminates in the conus medullaris at the T12/L1 vertebral body in adults Cauda equina Collection of ...

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Neurology
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