Archive

Tag: COVID19

The DisCoVeRy Trial: Remdesivir in COVID-19 – An Expensive Version of Tamiflu?

Background: Since the beginning of the pandemic, hundreds of trials have been  performed looking at medications with the potential to be repurposed for use against COVID19. To date, no antiviral medications directed at SARS-CoV-2 have shown any convincing evidence of ...

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Infectious Disease

The TOGETHER Trial: COVID-19 and Fluvoxamine Take Two

Background: Despite having a safe and effective set of vaccines for COVID-19, there have been some low resource countries in which it has been very challenging in getting the vaccine allocated.  Therefore, identifying an inexpensive, widely available, and effective therapy ...

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Awake Proning for COVID-19 Acute Hypoxemic Respiratory Failure

Background: Awake prone positioning was an intervention adopted early in the COVID-19 pandemic for patients with hypoxemic respiratory failure.  Unfortunately, many early trials were not powered to show improvements in oxygenation, escalation of respiratory support, or mortality. The one meta-analysis ...

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ResuscitationThoracic and Respiratory

It’s All About Risk: BNT162b2 mRNA COVID-19 Vaccination vs Natural Infection

Background: The world has been involved in mass vaccination efforts for the last nine months. Since the vaccines were approved, billions of doses have been administered.  Initial trials showed the COVID-19 vaccines to be efficacious and safe.   However, assessing vaccine ...

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Infectious Disease

RECOVERY RS: CPAP vs HFNO vs Conventional Oxygen Therapy in COVID-19

Background: Much of the last two years has been both a complete blur and indelibly memorable. This dichotomy is encapsulated by the rapid changes and updates in medical management and hospital algorithms coupled with the memories of frightened faces of ...

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Thoracic and Respiratory

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