Archive

Rebel Category: REBEL Crit

TNK vs tPA — The ORIGINAL Trial

The American Heart Association and the European Stroke Organization have updated their guidelines to recommend TNK as an alternative to tPA in patients eligible for thrombolysis. TNK, a bioengineered variant of tPA, has some advantages, including its single-dose administration, fibrin ...

Read More
Neurology

How Accurate are Blood Gas Electrolyte Measurements?

Bottom Line Up Top: Blood gas electrolytes closely correlate with serum measurements and can be used under most circumstances to guide clinical care. Clinical Scenario: A 62 year old woman with a history of HTN, ESRD on MWF dialysis presents ...

Read More
Endocrine, Metabolic, Fluid, and Electrolytes

IVC Distensibility Index vs Collapsibility Index: Using the Correct Index

Background  In 1979, Hiroshi Natori was the first to appreciate the sonographic changes that occur in the inferior vena cava (IVC)’s diameter with ventilation in spontaneously breathing patients, mechanically ventilated patients, and those with carcinogenic and tuberculoid cardiac tamponade.1 They ...

Read More
CardiovascularResuscitationThoracic and Respiratory

Threading the Needle: Bougie-First Intubation

Background: In 2018, the BEAM Trial, a small single-center randomized clinical trial, conducted in the emergency department at Hennepin County Medical Center, demonstrated that bougie use significantly increased the first-attempt intubation success rate compared to the endotracheal tube with stylet ...

Read More
Procedures and SkillsResuscitation

Is Pip-Tazo Harming Sepsis Patients?

Background: Patients with sepsis are routinely treated with empiric broad-spectrum antibiotics while awaiting source identification, as recommended by the surviving sepsis campaign.2 Vancomycin, in combination with either piperacillin-tazobactam or cefepime, is commonly used for empiric treatment in these cases. Literature ...

Read More
Infectious Disease

Sponsored