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Rebel Category: REBEL Crit

The TASC Trial: Therapeutic vs Prophylactic Anticoagulation for Acute Chest Syndrome

In adults with sickle cell disease hospitalized for acute chest syndrome (ACS) without pulmonary artery macrothrombosis, does therapeutic-dose anticoagulation with tinzaparin shorten ACS duration compared with prophylactic-dose anticoagulation?

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Hematology and Oncology
Healthcare team preparing for rapid sequence intubation with an endotracheal tube and oxygen mask, illustrating rocuronium vs succinylcholine for RSI, awareness, paralysis, and post-intubation sedation.

Rocuronium vs Succinylcholine for RSI: Awareness, Paralysis, and Post-Intubation Sedation

Does rocuronium delay post-intubation sedation and analgesia compared with succinylcholine after RSI? This REBEL EM post appraises a retrospective ED cohort study examining paralytic choice, analgosedation timing, and the risk of awareness during paralysis.

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Procedures and SkillsResuscitation

Meta-Analysis of Norepinephrine vs Epinephrine After Cardiac Arrest

Is there a lower rate of recurrent cardiac arrest in patients who received norepinephrine versus epinephrine post-ROSC?

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CardiovascularResuscitation

HI-PEITHO Trial: Ultrasound-facilitated, Catheter Directed Fibrinolysis for PE

In patients with intermediate-risk pulmonary embolism (PE), does ultrasound-facilitated, catheter-directed fibrinolysis (US-CDT) plus anticoagulation improve clinical outcomes compared to anticoagulation alone?

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ResuscitationThoracic and Respiratory

Alternate Defibrillation Strategies for Refractory Ventricular Fibrillation

In this secondary analysis of the DOSE-VF Trial, one of the first RCTs assessing alternative defibrillation strategies in OHCA, the authors reviewed defibrillation files from the initial study to answer whether reduced time in VF between shocks could explain the ...

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CardiovascularResuscitation
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