Rebel Category: REBEL Crit

Effect of Sepsis Bundle (SEP-1) Compliance and Implementation on Mortality

by Melissa Smith, MD, RN and Maren Leibowitz, MD posted August 24, 2026 No Comments

Is there any moderate or high-level evidence that SEP-1 compliance and/or implementation is associated with improvement in sepsis mortality?

Infectious DiseaseResuscitation

SPICE III Trial: Does Early Dexmedetomidine Improve Survival in Mechanically Ventilated ICU Patients?

by Dorian Alexander, MD posted August 17, 2026 No Comments

Is HFNC as effective as NIV in reducing respiratory rate and improving respiratory distress within 2 hours in ACPE?

Neurology

HFNC vs. NIV in Acute Cardiogenic Pulmonary Edema: Go with the Flow?

by Ryan Johnson, MD and Dorian Alexander, MD posted July 20, 2026 No Comments

Is HFNC as effective as NIV in reducing respiratory rate and improving respiratory distress within 2 hours in ACPE?

Resuscitation

The TASC Trial: Therapeutic vs Prophylactic Anticoagulation for Acute Chest Syndrome

by Drs. Heba Ali Zakaria and David Zull posted July 13, 2026 No Comments

In adults with sickle cell disease hospitalized for acute chest syndrome (ACS) without pulmonary artery macrothrombosis, does therapeutic-dose anticoagulation with tinzaparin shorten ACS duration compared with prophylactic-dose anticoagulation?

Hematology and Oncology

Healthcare team preparing for rapid sequence intubation with an endotracheal tube and oxygen mask, illustrating rocuronium vs succinylcholine for RSI, awareness, paralysis, and post-intubation sedation.

Rocuronium vs Succinylcholine for RSI: Awareness, Paralysis, and Post-Intubation Sedation

by Amil Badoolah, DO posted June 22, 2026 No Comments

Does rocuronium delay post-intubation sedation and analgesia compared with succinylcholine after RSI? This REBEL EM post appraises a retrospective ED cohort study examining paralytic choice, analgosedation timing, and the risk of awareness during paralysis.

Procedures and SkillsResuscitation

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