Rebel Category: REBEL Crit

The A2B Trial: Are Alpha-2 Agonists Better than Propofol for ICU Sedation?

by Dorian Alexander, MD posted September 21, 2026 Comments: No Comments

Does primary sedation with dexmedetomidine or clonidine reduce the time to successful extubation in mechanically ventilated critically ill patients compared to propofol-based sedation?

Neurology

Effect of Sepsis Bundle (SEP-1) Compliance and Implementation on Mortality

by Melissa Smith, MD, RN and Maren Leibowitz, MD posted August 24, 2026 Comments: No Comments

Is there any moderate or high-level evidence that SEP-1 compliance and/or implementation is associated with improvement in sepsis mortality?

Infectious DiseaseResuscitation

SPICE III Trial: Does Early Dexmedetomidine Improve Survival in Mechanically Ventilated ICU Patients?

by Dorian Alexander, MD posted August 17, 2026 Comments: No Comments

Is HFNC as effective as NIV in reducing respiratory rate and improving respiratory distress within 2 hours in ACPE?

Neurology

HFNC vs. NIV in Acute Cardiogenic Pulmonary Edema: Go with the Flow?

by Ryan Johnson, MD and Dorian Alexander, MD posted July 20, 2026 Comments: No Comments

Is HFNC as effective as NIV in reducing respiratory rate and improving respiratory distress within 2 hours in ACPE?

Resuscitation

The TASC Trial: Therapeutic vs Prophylactic Anticoagulation for Acute Chest Syndrome

by Drs. Heba Ali Zakaria and David Zull posted July 13, 2026 Comments: No Comments

In adults with sickle cell disease hospitalized for acute chest syndrome (ACS) without pulmonary artery macrothrombosis, does therapeutic-dose anticoagulation with tinzaparin shorten ACS duration compared with prophylactic-dose anticoagulation?

Hematology and Oncology