Archive

Rebel Category: REBEL Crit

The PEERLESS Trial: Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in Intermediate-Risk PE

The optimal treatment strategy for intermediate-risk (submassive) pulmonary embolism remains controversial. These patients are not in shock, but they have right ventricular (RV) dysfunction and myocardial injury, which are associated with higher risk for clinical decompensation and adverse outcomes.

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Thoracic and Respiratory

The Hope Trial: Alteplase 4.5–24 Hours After Stroke (CT Perfusion Selected)

The cornerstone of acute ischemic stroke (AIS) management involves timely reperfusion of the ischemic brain tissue. Intravenous thrombolysis with alteplase has been the standard of care for AIS within 4.5 hours of symptom onset, based on pivotal trials such as ...

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Neurology

Continuous Suctioning Doesn’t Hasten Hypoxemia

Prior research has shown that deep tracheal suctioning can result in more rapid development of hypoxemia. It is unclear if continuous suctioning during intubation poses a similar risk. Does the application of continuous suctioning during rapid sequence intubation (RSI) result ...

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Resuscitation

RENOVATE Trial: HFNC vs BPAP in Acute Respiratory Failure

With high flows, modest PEEP, and effective dead-space washout, HFNC can improve oxygenation and decrease work of breathing while preserving the ability to talk, cough, eat, and interact with staff and family. The RENOVATE trial set out to answer a ...

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ResuscitationThoracic and Respiratory

The RSI Trial: Ketamine vs Etomidate in Rapid Sequence Intubation

Etomidate or ketamine? The debate over the ideal agent for emergency rapid sequence intubation (RSI) has raged for years with no clear winner. Etomidate has been touted in the past for its rapid onset and minimal intrinsic effects on hemodynamics. ...

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ResuscitationThoracic and Respiratory

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