Archive

Medical Category: Toxicology

Do Patients with Opioid Dependence Benefit from Buprenorphine/Naloxone Treatment Initiation in the Emergency Department?

Background: North America’s current opioid crisis, much of it iatrogenic (2), has led to significant increases in ED visits associated with opioids (3). These patients often present after poisoning, in withdrawal, or with other health issues associated with their disease. It ...

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Toxicology

Should You Prescribe Oral Thiamine for Chronic Alcoholics?

Background: Alcoholism is a chronic disease with a staggering impact on society, costing the nation approximately 100 billion dollars per year, an expenditure greater than the costs associated with all cancers and respiratory diseases combined (Whiteman 2000). Large public hospital emergency ...

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Toxicology

Acute Salicylate Toxicity, Mechanical Ventilation, and Hemodialysis

Background: Salicylates are common substances that can be purchased over the counter. They are readily available, and in the setting of an overdose, can be fatal . Initially, as salicylates are metabolized, they can induce a respiratory alklalosis. This is ...

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Toxicology

Local Anesthetic Systemic Toxicity (LAST)

Definition: A life-threatening adverse reaction resulting from local anesthetic reaching significant systemic circulating levels. Local Anesthetic Systemic Toxicity (LAST) is rare and almost always occurs within minutes of injection of the local anesthetic. Causes: Injection of local anesthetic into the ...

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Toxicology

Baclofen Withdrawal

Definition: A dysfunctional condition in which removal of baclofen, an inhibitory neurotransmitter, from the central nervous system (CNS) causes CNS excitation.

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Toxicology

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