Archive

Author: Anand Swaminathan

The Utility of Amiodarone in Cardiac Arrest – Systematic Review and Meta-Analysis

Background: In 2016 the annual incidence of out-of-hospital cardiac arrest (OHCA) in the United States was roughly 360,000 and 209,000 for in-hospital cardiac arrest (IHCA) (Mozaffarian 2016). Though survival rates are relatively dismal, arrests in the setting of shock amenable ...

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Resuscitation

Impact of POCUS During Cardiac Arrest Resuscitation on Compression Pauses

The provision of high-quality compressions with minimal interruptions is central to the management of cardiac arrest. Along with defibrillation, high-quality compressions are the only interventions proven to improve patient-oriented outcomes. Recently, point-of-care ultrasound (POCUS) has gained greater use in cardiac ...

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Resuscitation

Occult Causes of Non-Response to Vasopressors

Intro: Vasoactive substances are powerful therapeutic medications that can boost a patient’s blood pressure and perfusion to target organs. They are often used in resuscitation to support tissue perfusion though their benefits are mostly unproven and may be harmful in ...

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Resuscitation

Icatibant Doesn’t Improve Outcomes in ACE-I Induced Angioedema

Angiotensin Converting Enzyme Inhibitors (ACE-I) are prescribed to millions of patients in the US. Though they are relatively safe, upper airway angioedema is one of the life-threatening adverse effects that we see frequently in the Emergency Department. Though this disorder ...

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Allergy and Immunology

Is Amiodarone Dead?

Background: Amiodarone is a class III antidysrhythmic first released for human use in 1962. As with other drugs in this class, amiodarone acts by blocking potassium channels thus prolonging the action potential. This, in turn, leads to a lengthening of depolarization ...

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CardiovascularResuscitation

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