Archive

Tag: Toxicology

REBEL Core Cast 120.0 – Salicylate Toxicity

Take Home Points Salicylates are a commonly used and widely prescribed xenobiotic due to their analgesic, anti-inflammatory, and anti-pyretic properties. Common preparations include aspirin, methyl-salicylate (Oil of Wintergreen), and bismuth-subsalicylate (Pepto-Bismol). Salicylate toxicity should be considered in the patient with …

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Toxicology

REBEL Core Cast 109.0 – Na Channel Blocker Poisoning

Take Home Points: In the context of poisoning, a “wide QRS” is anything greater than 100 milliseconds. A newly “wide QRS”, especially with hemodynamic instability, should prompt consideration of sodium channel blockade and not ventricular tachycardia. Treatment is guided by …

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Toxicology

REBEL Core Cast 90.0 – Methemoglobinemia

Take Home Points Methemoglobinemia can result from exposure to a number of different medications. The most common are dapsone and topical anesthetic agents (i.e. benzocaine) Consider the diagnosis in any patient with cyanosis and hypoxia that doesn’t respond to oxygen …

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Toxicology

Topical Capsaicin & Cannabinoid Hyperemesis Syndrome

Background Information: Cannabinoid Hyperemesis Syndrome (CHS) is characterized by the chronic use of cannabis paired with nausea, recurrent vomiting episodes and diffuse abdominal pain.1 The pathophysiology of CHS remains unclear and large systematic reviews of the literature have recommended up to …

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Abdominal and GastroinstestinalToxicology

Association of Maternal First-Trimester Ondansetron Use with Cardiac Malformations and Oral Clefts in Newborns

Background Information: Nausea and vomiting during pregnancy most commonly occurs during the first trimester. If left untreated, the development of hyperemesis gravidarum can lead to further complications characterized by dehydration and electrolyte abnormalities.1 Ondansetron, a 5-HT3 receptor antagonist has quickly …

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Obstetrics and GynecologyToxicology

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