Archive

Tag: thrombolysis

REBEL Cast Ep 105: Thrombolysis Before Endovascular Therapy for LVO Acute Ischemic Stroke

In this episode of REBEL Cast, Anand Swaminathan and I sit down to discuss the utility of thrombolysis prior to Endovascular therapy for LVO acute ischemic stroke.  The discussion is broken up into two potential scenarios: Not all facilities are ...

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Neurology

Rebellion21: Stroke – Tiiii-ii-iiime is on Your Side, or is it? via George Willis, MD

In this 15-minute lecture from Rebellion in EM 2021, George Willis, MD discusses acute ischemic stroke and the evidence base for and against thrombolysis.

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Neurology

Thrombolysis in Acute Ischemic Stroke: Now We Have No Positive RCTs

Background: The scientific process in medicine is complicated. Obtaining high-quality data to guide management requires hypothesis formulation, data to support the hypothesis and study replication. Time and again beneficial findings in therapeutic studies fail to be replicated in subsequent studies. ...

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Neurology

The DIRECT-MT Trial: Are Systemic Lytics Necessary in LVO Treatment?

Background: The publication of the MR CLEAN trial in January 2015 changed the face of ischemic stroke care. This was the first study demonstrating a benefit to endovascular treatment of a specific subset of ischemic stroke patients: those with a ...

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Neurology

Catheter Directed Thrombolysis: The Magic Bullet for Submassive Pulmonary Embolism?

Background: When evaluating therapeutic options for PE, there are three categories in my mind: Subsegmental, Submassive, and Massive. For simplicity sake lets just say subsegmental PEs get treated with anticoagulation and massive PEs get treated with thrombolysis. The submassive category ...

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Thoracic and Respiratory

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