Archive

Tag: Sepsis

Episode 37 – Definitions and Identification of Sepsis: Sepsis 2.0 vs Sepsis 3.0

Background: Just a few months ago the surviving sepsis campaign published their international guidelines for management of sepsis and septic shock .  There has been a lot of talk in the FOAM world about sepsis 3.0 and this is the ...

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Infectious Disease

The Marik Protocol: Have We Found a “Cure” for Severe Sepsis and Septic Shock?

Background: The overall mortality in sepsis has decreased quite a bit in the last decade or so, however for a subset of patients, like those with Septic Shock, the mortality still remains high (as high as 50%).  There have been ...

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Infectious Disease

Is Fever the New Hotness in Sepsis?

Background: With the introduction of sepsis 3.0, came the quick sepsis related organ failure assessment (qSOFA) score. The purpose of this score is supposed to be a bedside tool to help predict which patients are at the greatest risk of ...

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Infectious Disease

The HYPRESS Trial: Early Steroids to Prevent Septic Shock

Background: The most recent surviving sepsis campaign recommends the use of hydrocortisone in patients with refractory septic shock (i.e. vasopressor dependent).  However, the use of hydrocortisone in severe sepsis without shock still remains a very controversial topic. Recommendations for hydrocortisone ...

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Infectious Disease

Time to Antibiotics in Sepsis: A Metric Not Supported by “High Quality” Evidence

Background: Some of the major take home points from the sepsis trilogy of studies recently published (ProCESS, ARISE, and ProMISe) was that early identification of patients with sepsis, early intravenous fluids, and timely, appropriate broad-spectrum antibiotics is key to decreasing ...

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Infectious Disease

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