Archive

Tag: Sepsis

REBEL Cast Ep 76: The 65 Trial – Shooting for a Lower MAP in Older Patients with Sepsis?

Background: Vasopressors are often used to improve hypotension and perfusion in an effort to decrease mortality of patients with septic shock. Mean arterial pressure (MAP) of >65mmHg has typically been used to guide vasopressor therapy in most patients and higher ...

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Infectious DiseaseResuscitation

The FABLED Trial: Blood Cultures 1st, Then Antibiotics in Sepsis

Background: The cornerstones of sepsis management include early identification, early antimicrobial administration, and source control.  The Surviving Sepsis Campaign guidelines recommend that blood cultures be drawn before starting antimicrobial therapy, however, obtaining cultures prior to antibiotics may be challenging due ...

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Infectious Disease

REBEL Cast Ep74 – Is it all About the VITAMINS in Sepsis?

Background: The combination of vitamin C, hydrocortisone and thiamine in sepsis has been a topic of hot debate in the past couple years.  There is a hypothetical pathophysiological basis to make an argument for the use of this combination of ...

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Infectious DiseaseResuscitation

CITRIS-ALI: Vitamin C in Patients with Sepsis and Severe Acute Respiratory Failure

Background: In 2016, Paul Marik published a study in Chest demonstrating a decrease in hospital mortality of 32% for sepsis patients treated with vitamin C, thiamine and hydrocortisone.  The Marik protocol(as it has come to be known), entails IV ...

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Infectious Disease

Are Antibiotics for Sepsis in One Hour Feasible in the ED?

Background: Despite minimal high-quality supporting evidence (Seymour 2017, Liu 2017, Ferrer 2014, Sterling 2015), regulatory bodies have pushed for benchmark times for administration of antibiotics in patients with sepsis. While most clinicians would agree that in patients with septic shock ...

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Infectious Disease

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