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Tag: Neurology

Endovascular Therapy for Acute Ischemic Stroke: The New Shiny Toy in Stroke Care?

The shiny new toy in stroke treatment is endovascular therapy.  There have now been 12 randomized controlled trials (RCTs) on endovascular stroke therapy (EST), with eight of the last nine showing positive results – stunningly positive.  This flood of positive …

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Neurology

Extending the tPA Window to 4.5 – 9 Hours in Acute Ischemic Stroke (AIS)?

Background: No matter which side of the debate you sit on in regard to systemic thrombolysis in acute ischemic stroke (AIS), there is one truth: systems have undergone major changes to ensure tPA is offered to patients in the ≤4.5-hour window.  …

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Neurology

The Ottawa SAH Clinical Decision Rule

Background: Headache is a common presentation to the emergency department  (ED) accounting for 2% of all visits [1].  Of the patients that present with headache,1 – 3% will be due to a subarachnoid hemorrhage (SAH) [1]. SAH is a true diagnostic …

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Neurology

PRISMS Trial: Alteplase vs. Aspirin in Minor Stroke

Background: Despite serious concerns about the role of alteplase in the management of acute ischemic stroke including, but not limited to, significant conflicts of interest, unbalanced baseline patient characteristics, systematic devaluation of contrary data, lack of reproduced benefit and low …

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Neurology

TICH-2: TXA for Spontaneous ICH?

Background: Spontaneous, non-traumatic intracerebral hemorrhage, is one of the only stroke subtypes without a proven treatment. It is not as common as ischemic stroke, representing up to 20% of all strokes, but it accounts for almost half of all stroke deaths worldwide.  …

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Neurology

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