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Tag: Alcohol Withdrawal

Return Encounters in Emergency Department Patients Treated with Phenobarbital Versus Benzodiazepines for Alcohol Withdrawal

Background: The emergency department is frequently visited by patients suffering from symptomatic alcohol withdrawal, and the traditional management has been dominated by repeated doses of benzodiazepines.1, 2 Phenobarbital has been studied as an alternative or adjunct to benzodiazepines with encouraging …

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Toxicology

REBEL Cast Ep115 – Phenobarbital vs Lorazepam in Alcohol Withdrawal

Background information: Alcohol has potentiating effects on the inhibitory GABA neurotransmission system and inhibitory effects on the excitatory glutamate neurotransmission system. Chronic alcohol use causes changes to preserve homeostasis, and when the stimulus is removed, alcohol withdrawal results due to …

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Toxicology

Journal Abstracts and Why You Should Continue to Use Phenobarbital in Alcohol Withdrawal Syndrome for Patients Requiring Admission

Background: The mainstay of treatment for alcohol withdrawal syndrome is a symptom-triggered approach using benzodiazepines. Phenobarbital, however, is an interesting agent in this scenario for several reasons. It is famous for  it is long duration of action. IV Phenobarbital has an …

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Toxicology

Benzodiazepine-Refractory Alcohol Withdrawal

Background: Severe alcohol withdrawal syndrome (AWS) accounts for only 10% of the roughly 500,000 annual cases of AWS episodes that require pharmacologic treatment. AWS is characterized by an imbalance between inhibitory GABA and excitatory NMDA receptor stimulation secondary to chronic ethanol …

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Toxicology

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