Archive

Medical Category: Neurology

Minimal icon-style illustration of eyes, mouth, motor, respiration

MDCalc Wars: GCS Alternatives in the ED: SMS and FOUR Score

Need a quick, reliable coma scale in real ED chaos? SMS simplifies assessment, while FOUR adds brainstem and respiratory data when it matters most.

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NeurologyTrauma

The Hope Trial: Alteplase 4.5–24 Hours After Stroke (CT Perfusion Selected)

The cornerstone of acute ischemic stroke (AIS) management involves timely reperfusion of the ischemic brain tissue. Intravenous thrombolysis with alteplase has been the standard of care for AIS within 4.5 hours of symptom onset, based on pivotal trials such as ...

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Neurology

Seizing the Evidence: Should We Consider Ketamine’s Place in Seizure Protocols?

Ketamine was first introduced for human use in 1965 and has been widely utilized as a general anesthetic with an excellent safety profile (Mion 2017, Dorandeu 2013). Ketamine works on several receptors, resulting in various actions such as anesthesia, analgesia, ...

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Neurology

Midazolam vs Ketamine as Second Line in Status Epilepticus

Status epilepticus is traditionally defined as a seizure lasting ≥5 minutes or recurrent seizures without return to baseline in between. It is a neurologic emergency associated with increased morbidity and mortality the longer it persists. Some complications include cardiac arrhythmias, ...

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NeurologyResuscitation

TNK vs tPA — The ORIGINAL Trial

The American Heart Association and the European Stroke Organization have updated their guidelines to recommend TNK as an alternative to tPA in patients eligible for thrombolysis. TNK, a bioengineered variant of tPA, has some advantages, including its single-dose administration, fibrin ...

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Neurology

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