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Tag: Toxicology

REBEL Core Cast 90.0 – Methemoglobinemia

Take Home Points Methemoglobinemia can result from exposure to a number of different medications. The most common are dapsone and topical anesthetic agents (i.e. benzocaine) Consider the diagnosis in any patient with cyanosis and hypoxia that doesn’t respond to oxygen …

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Toxicology

Topical Capsaicin & Cannabinoid Hyperemesis Syndrome

Background Information: Cannabinoid Hyperemesis Syndrome (CHS) is characterized by the chronic use of cannabis paired with nausea, recurrent vomiting episodes and diffuse abdominal pain.1 The pathophysiology of CHS remains unclear and large systematic reviews of the literature have recommended up to …

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Abdominal and GastroinstestinalToxicology

Association of Maternal First-Trimester Ondansetron Use with Cardiac Malformations and Oral Clefts in Newborns

Background Information: Nausea and vomiting during pregnancy most commonly occurs during the first trimester. If left untreated, the development of hyperemesis gravidarum can lead to further complications characterized by dehydration and electrolyte abnormalities.1 Ondansetron, a 5-HT3 receptor antagonist has quickly …

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Obstetrics and GynecologyToxicology

REBEL Core Cast 5.0 – Accidental Hypothermia

Take Home Points: Hypothermia is neuroprotective and patients can survive prolonged periods of cardiac arrest. Termination of resuscitative efforts in cardiac arrest should not considered until the patient is >32°C or has a K > 12 mEq/L Active internal rewarming …

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Environmental

The HOUR Trial: Clinical Decision Rule for Opioid Overdose Patients in the Emergency Department

Background Information: In 2017, more than two-thirds of the 70,000 drug overdose deaths in the United States involved an opioid.1 Many emergency departments are affected as opioid overdoses increased 30% from July 2016 through September 2017 in 52 areas in …

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Toxicology

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