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Tag: Tenecteplase

Tenecteplase for Thrombolysis of AIS?

Background: Alteplase has been the accepted thrombolytic for acute ischemic stroke (AIS) for 25 years. However, recent data has emerged regarding tenectaplase as an alternative. ¬†Tenecteplase is a modified form of alteplase, with a lower cost and more favorable pharmacokinetic …

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Neurology

EXTEND-IA TNK Part II – What Dose of Tenecteplase is the Right Dose?

Background: The publication of the MR CLEAN trial in January 2015 changed the face of ischemic stroke care. This was the first study demonstrating a benefit to endovascular treatment of a specific subset of ischemic stroke patients: those with a …

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Neurology

Tenecteplase versus Alteplase before Endovascular Therapy for Ischemic Stroke (EXTEND-IA TNK)

Background: Alteplase is a tissue plasminogen activator that is approved for use prior to thrombectomy in ischemic strokes with the goal of reperfusion to ischemic areas of the brain. Tenecteplase is a recombinant enzyme derived from alteplase that is more …

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Neurology

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