January 2015 REBELCast

10 Jan
January 10, 2015

REBELCastWelcome to the January 2015 REBELCast, where Swami and I are going to tackle a very important scenario that comes up in the daily practice of not only Emergency Medicine, but also in Medicine.  Today we are going to specifically tackle one topic:

Topic: Is the use of cephalosporin antibiotics in patients with a history of penicillin class antibiotics safe?

 January 2015 REBELCast Podcast

Click here for Direct Download of Podcast

What clinical question will be covered in the January 2015 REBELCast?

Question: Can we give cephalosporins to patients with a history of penicillin allergy without risking a significant allergic reaction?

OR: Is the classic teaching of a 10% cross-reactivity between cephalosporin and penicillin antibiotics true?

What specific article will we be covering?

Article: Campagna JD et al. The use of cephalosporns in PCN-allergic patients. JEM 2012; 42(5): 612-20. PMID: 21742459

What is the clinical bottom line for the above clinical question:

Bottom Line: The often quoted 10% “cross-reactivity” rate between penicillins and cephalosporins is inaccurate based on the best available evidence. The true rate is somewhere between 1 – 3%.

Cephalosporin-Penicillin Cross Reactivity Summary

Summary Table by Bryan Hayes, PharmD

January 2015 REBELCast Show Notes

For more on the above topic checkout:

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Salim Rezaie

Emergency Physician at Greater San Antonio Emergency Physicians (GSEP)
Creator & Founder of R.E.B.E.L. EM

Latest posts by Salim Rezaie (see all)

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