Tag: Modified Rankin Scale

The Hope Trial: Alteplase 4.5–24 Hours After Stroke (CT Perfusion Selected)

by Carlton Watson, MD MSc posted February 16, 2026 No Comments

The cornerstone of acute ischemic stroke (AIS) management involves timely reperfusion of the ischemic brain tissue. Intravenous thrombolysis with alteplase has been the standard of care for AIS within 4.5 hours of symptom onset, based on pivotal trials such as ...

Neurology

TAME Trial: Mild Hypercapnia vs Normocapnia in Out-of-Hospital Cardiac Arrest

by Hrant Gevorgian posted August 21, 2023 No Comments

Background Information: Cardiac arrest is a devastating event that imposes considerable human and financial burdens. While it is widely recognized that cardiac arrest leads to brain injury, what is often overlooked is the persistent cerebral hypoperfusion that continues even after ...

CardiovascularResuscitation