August 27, 2020

The Coronaviridae family and its genera coronaviruses have been implicated as having neurotropic and neuroinvasive capabilities in human hosts (Bohmwald 2018). They have been associated with the development of neuropsychiatric symptoms, seizure activity, encephalomyelitis, acute flaccid paralysis, cerebral venous sinus thrombosis, Guillain-Barré syndrome, as well as cerebrovascular disease (Bohmwald 2018, St Jean 2004). Recently, there has been a growing body of evidence supporting the association of SARS-CoV2 with neurological abnormalities. A systematic review looking at the incidence of secondary neurological disease in patients diagnosed with SARS-CoV2 found rates to vary from 6-36.4% (Herman 2020). At the time of this submission, there have been ten reports of acute transverse myelitis (ATM) attributed to SARS-CoV2, and others are currently being submitted or are in pre-print at this time (See infographic below). ATM has a varied presentation and is associated with significant morbidity and mortality that necessitates increased awareness and vigilance on the part of the clinician. This has become especially important in light of a possible causal link of ATM to SARS-CoV2 with emerging cases during the COVID-19 pandemic. Here, we review the salient features of infectious ATM (both para-infectious and post-infectious) to increase recognition of this disease entity.