Rebel Category: REBEL CME

REBEL Cast Ep74 – Is it all About the VITAMINS in Sepsis?

Background: The combination of vitamin C, hydrocortisone and thiamine in sepsis has been a topic of hot debate in the past couple years.  There is a hypothetical pathophysiological basis to make an argument for the use of this combination of …

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Infectious DiseaseResuscitation

REBEL Cast Ep73: Are Peripheral Vasopressors Safe?

Background: Traditionally, vasopressors have been given through central venous catheters (CVCs) in the critically ill.However, the time it takes to place a CVC is time a patient could potentially remain hypotensive. Early initiation of vasopressors may be associated with reduced …

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REBEL Cast Ep70 – Time to Antibiotics in Sepsis

Background: Antibiotics are one of the cornerstones of therapy in the treatment of sepsis/septic shock, however according to the Surviving Sepsis Campaign (SSC) guidelines, time to antibiotics is a core measure, though there is weak evidence in support of this.  Most …

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Infectious Disease

REBEL Cast Episode 67: EXTEND-ing Times for Systemic Thrombolysis in Acute Ischemic Stroke?

Background: Despite the lack of replication of the NINDS & ECASS-3 trials, guidelines recommend the use of tPA in the ≤4.5hr window after the onset of symptoms of acute ischemic stroke [2]. These recommendations used non-contrast computed tomography (NCHCT) for the …

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All You Need to Know About Measles

Background: In 2000, the U.S. achieved the elimination of measles, defined as the absence of sustained transmission of the virus for more than 12 months [3,7]. Unfortunately, this success was short lived.  According to the CDC, 555 cases of measles have …

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Infectious DiseasePediatrics